Literature DB >> 22497765

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Willmen Youngsaye1, Chris Dockendorff, Benjamin Vincent, Cathy L Hartland, Joshua A Bittker, Sivaraman Dandapani, Michelle Palmer, Luke Whitesell, Susan Lindquist, Stuart L Schreiber, Benito Munoz.   

Abstract

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22497765      PMCID： PMC3386803          DOI： 10.1016/j.bmcl.2012.02.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

1.  Characterization of a novel, broad-based fungicidal activity for the antiarrhythmic drug amiodarone.

Authors:  William E Courchesne
Journal:  J Pharmacol Exp Ther       Date:  2002-01       Impact factor: 4.030

2.  Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

Authors:  Willmen Youngsaye; Benjamin Vincent; Cathy L Hartland; Barbara J Morgan; Sara J Buhrlage; Stephen Johnston; Joshua A Bittker; Lawrence MacPherson; Sivaraman Dandapani; Michelle Palmer; Luke Whitesell; Susan Lindquist; Stuart L Schreiber; Benito Munoz
Journal:  Bioorg Med Chem Lett       Date:  2011-06-30       Impact factor: 2.823

3.  Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis.

Authors:  Monika Sharma; Raman Manoharlal; Arvind Singh Negi; Rajendra Prasad
Journal:  FEMS Yeast Res       Date:  2010-04-23       Impact factor: 2.796

4.  Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis due to Candida albicans.

Authors:  A Louie; W Liu; D A Miller; A C Sucke; Q F Liu; G L Drusano; M Mayers; M H Miller
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

5.  Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models.

Authors:  Joseph Meletiadis; Paul E Verweij; Debbie T A TeDorsthorst; Jacques F G M Meis; Johan W Mouton
Journal:  Med Mycol       Date:  2005-03       Impact factor: 4.076

6.  Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans.

Authors:  O Marchetti; P Moreillon; M P Glauser; J Bille; D Sanglard
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

7.  Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans.

Authors:  Soledad Gamarra; Elousa Maria F Rocha; Yong-Qiang Zhang; Steven Park; Rajini Rao; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

8.  The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms.

Authors:  H EAGLE; A D MUSSELMAN
Journal:  J Exp Med       Date:  1948-07       Impact factor: 14.307

9.  Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp.

Authors:  Jessica A Digirolamo; Xing-Cong Li; Melissa R Jacob; Alice M Clark; Daneel Ferreira
Journal:  J Nat Prod       Date:  2009-08       Impact factor: 4.050

10.  Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump.

Authors:  X-L Guo; P Leng; Y Yang; L-G Yu; H-X Lou
Journal:  J Appl Microbiol       Date:  2008-01-09       Impact factor: 3.772
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  9 in total

1.  Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans.

Authors:  Aaron D Mood; Ilandari Dewage Udara Anulal Premachandra; Stanley Hiew; Fuqiang Wang; Kevin A Scott; Nathan J Oldenhuis; Haoping Liu; David L Van Vranken
Journal:  ACS Med Chem Lett       Date:  2017-01-11       Impact factor: 4.345

Review 2.  Antifungal drug development: challenges, unmet clinical needs, and new approaches.

Authors:  Terry Roemer; Damian J Krysan
Journal:  Cold Spring Harb Perspect Med       Date:  2014-05-01       Impact factor: 6.915

Review 3.  Combinatorial strategies for combating invasive fungal infections.

Authors:  Michaela Spitzer; Nicole Robbins; Gerard D Wright
Journal:  Virulence       Date:  2016-06-07       Impact factor: 5.882

4.  The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.

Authors:  Kristy Koselny; Julianne Green; Louis DiDone; Justin P Halterman; Annette W Fothergill; Nathan P Wiederhold; Thomas F Patterson; Melanie T Cushion; Chad Rappelye; Melanie Wellington; Damian J Krysan
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

5.  A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.

Authors:  Benjamin M Vincent; Jean-Baptiste Langlois; Raja Srinivas; Alex K Lancaster; Ruth Scherz-Shouval; Luke Whitesell; Bruce Tidor; Stephen L Buchwald; Susan Lindquist
Journal:  Cell Chem Biol       Date:  2016-08-11       Impact factor: 8.116

6.  Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans.

Authors:  Ilandari Dewage Udara Anulal Premachandra; Kevin A Scott; Chengtian Shen; Fuqiang Wang; Shelley Lane; Haoping Liu; David L Van Vranken
Journal:  ChemMedChem       Date:  2015-08-12       Impact factor: 3.466

7.  Synthesis and synergistic antifungal effects of monoketone derivatives of curcumin against fluconazole-resistant Candida spp.

Authors:  Fei Zhao; Huai-Huai Dong; Yuan-Hua Wang; Tian-Yi Wang; Ze-Hao Yan; Fang Yan; Da-Zhi Zhang; Ying-Ying Cao; Yong-Sheng Jin
Journal:  Medchemcomm       Date:  2017-03-17       Impact factor: 3.597

8.  ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.

Authors:  Willmen Youngsaye; Cathy L Hartland; Barbara J Morgan; Amal Ting; Partha P Nag; Benjamin Vincent; Carrie A Mosher; Joshua A Bittker; Sivaraman Dandapani; Michelle Palmer; Luke Whitesell; Susan Lindquist; Stuart L Schreiber; Benito Munoz
Journal:  Beilstein J Org Chem       Date:  2013-07-26       Impact factor: 2.883

9.  Suppression of Fluconazole Resistant Candida albicans Biofilm Formation and Filamentation by Methylindole Derivatives.

Authors:  Jin-Hyung Lee; Yong-Guy Kim; Vivek Kumar Gupta; Ranjith Kumar Manoharan; Jintae Lee
Journal:  Front Microbiol       Date:  2018-11-06       Impact factor: 5.640
  9 in total

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