Literature DB >> 19270702

Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2.

Antonis Kirmizis1, Helena Santos-Rosa, Christopher J Penkett, Michael A Singer, Roland D Green, Tony Kouzarides.   

Abstract

Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit histone H3 Lys4 (H3K4) methylation; (ii) it is present throughout the coding region of genes; and (iii) it correlates with active transcription. Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression.

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Year:  2009        PMID： 19270702      PMCID： PMC3350867          DOI： 10.1038/nsmb.1569

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  14 in total

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Authors:  B D Strahl; S D Briggs; C J Brame; J A Caldwell; S S Koh; H Ma; R G Cook; J Shabanowitz; D F Hunt; M R Stallcup; C D Allis
Journal:  Curr Biol       Date:  2001-06-26       Impact factor: 10.834

2.  Reading signals on the nucleosome with a new nomenclature for modified histones.

Authors:  Bryan M Turner
Journal:  Nat Struct Mol Biol       Date:  2005-02       Impact factor: 15.369

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Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

Review 4.  Chromatin modifications and their function.

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Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

5.  Methylation at arginine 17 of histone H3 is linked to gene activation.

Authors:  Uta-Maria Bauer; Sylvain Daujat; Søren J Nielsen; Karl Nightingale; Tony Kouzarides
Journal:  EMBO Rep       Date:  2001-12-19       Impact factor: 8.807

6.  Dissecting the regulatory circuitry of a eukaryotic genome.

Authors:  F C Holstege; E G Jennings; J J Wyrick; T I Lee; C J Hengartner; M R Green; T R Golub; E S Lander; R A Young
Journal:  Cell       Date:  1998-11-25       Impact factor: 41.582

Review 7.  Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

Authors:  Alexander J Ruthenburg; C David Allis; Joanna Wysocka
Journal:  Mol Cell       Date:  2007-01-12       Impact factor: 17.970

8.  Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.

Authors:  H Ma; C T Baumann; H Li; B D Strahl; R Rice; M A Jelinek; D W Aswad; C D Allis; G L Hager; M R Stallcup
Journal:  Curr Biol       Date:  2001-12-11       Impact factor: 10.834

9.  Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.

Authors:  H Wang; Z Q Huang; L Xia; Q Feng; H Erdjument-Bromage; B D Strahl; S D Briggs; C D Allis; J Wong; P Tempst; Y Zhang
Journal:  Science       Date:  2001-05-31       Impact factor: 47.728

10.  A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism.

Authors:  Ted M Lakowski; Adam Frankel
Journal:  J Biol Chem       Date:  2008-02-08       Impact factor: 5.157
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  23 in total

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2.  In vivo residue-specific histone methylation dynamics.

Authors:  Barry M Zee; Rebecca S Levin; Bo Xu; Gary LeRoy; Ned S Wingreen; Benjamin A Garcia
Journal:  J Biol Chem       Date:  2009-11-23       Impact factor: 5.157

Review 3.  Protein arginine methylation in parasitic protozoa.

Authors:  John C Fisk; Laurie K Read
Journal:  Eukaryot Cell       Date:  2011-06-17

Review 4.  Chatting histone modifications in mammals.

Authors:  Annalisa Izzo; Robert Schneider
Journal:  Brief Funct Genomics       Date:  2010-12       Impact factor: 4.241

Review 5.  Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.

Authors:  Robert H Cichewicz
Journal:  Nat Prod Rep       Date:  2009-10-27       Impact factor: 13.423

Review 6.  Quantitative proteomic analysis of histone modifications.

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7.  Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-25       Impact factor: 11.205

8.  Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation.

Authors:  Xing-Jun Cao; Barry M Zee; Benjamin A Garcia
Journal:  Methods Mol Biol       Date:  2013

Review 9.  Protein arginine methylation: a prominent modification and its demethylation.

Authors:  Juste Wesche; Sarah Kühn; Benedikt M Kessler; Maayan Salton; Alexander Wolf
Journal:  Cell Mol Life Sci       Date:  2017-03-31       Impact factor: 9.261

10.  Decoupling epigenetic and genetic effects through systematic analysis of gene position.

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Journal:  Cell Rep       Date:  2013-01-03       Impact factor: 9.423
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