Literature DB >> 19252499

Inhibition of Wnt signaling by Dishevelled PDZ peptides.

Yingnan Zhang1, Brent A Appleton, Christian Wiesmann, Ted Lau, Mike Costa, Rami N Hannoush, Sachdev S Sidhu.   

Abstract

Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/beta-catenin signaling in cells, showing that Dishevelled PDZ domains are potential targets for small-molecule cancer therapeutics.

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Year:  2009        PMID： 19252499     DOI： 10.1038/nchembio.152

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  18 in total

1.  Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.

Authors:  Nicholas J Skelton; Michael F T Koehler; Kerry Zobel; Wai Lee Wong; Sherry Yeh; M Theresa Pisabarro; Jian Ping Yin; Laurence A Lasky; Sachdev S Sidhu
Journal:  J Biol Chem       Date:  2002-11-20       Impact factor: 5.157

Review 2.  The many ways of Wnt in cancer.

Authors:  Paul Polakis
Journal:  Curr Opin Genet Dev       Date:  2007-02       Impact factor: 5.578

3.  Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.

Authors:  L Li; H Yuan; W Xie; J Mao; A M Caruso; A McMahon; D J Sussman; D Wu
Journal:  J Biol Chem       Date:  1999-01-01       Impact factor: 5.157

Review 4.  Trojan peptides: the penetratin system for intracellular delivery.

Authors:  D Derossi; G Chassaing; A Prochiantz
Journal:  Trends Cell Biol       Date:  1998-02       Impact factor: 20.808

5.  Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.

Authors:  Jianbo Wang; Natasha S Hamblet; Sharayne Mark; Mary E Dickinson; Brendan C Brinkman; Neil Segil; Scott E Fraser; Ping Chen; John B Wallingford; Anthony Wynshaw-Boris
Journal:  Development       Date:  2006-03-29       Impact factor: 6.868

6.  Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.

Authors:  J D Axelrod; J R Miller; J M Shulman; R T Moon; N Perrimon
Journal:  Genes Dev       Date:  1998-08-15       Impact factor: 11.361

7.  Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression.

Authors:  Kazutsugu Uematsu; Biao He; Liang You; Zhidong Xu; Frank McCormick; David Mark Jablons
Journal:  Oncogene       Date:  2003-10-16       Impact factor: 9.867

8.  Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

Authors:  Hing-C Wong; Audrey Bourdelas; Anke Krauss; Ho-Jin Lee; Youming Shao; Dianqing Wu; Marek Mlodzik; De-Li Shi; Jie Zheng
Journal:  Mol Cell       Date:  2003-11       Impact factor: 17.970

Review 9.  Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.

Authors:  Keith A Wharton
Journal:  Dev Biol       Date:  2003-01-01       Impact factor: 3.582

10.  Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.

Authors:  Neeraj Mahindroo; Chandanamali Punchihewa; Allison M Bail; Naoaki Fujii
Journal:  Bioorg Med Chem Lett       Date:  2007-12-23       Impact factor: 2.823
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  77 in total

Review 1.  Protein binding specificity versus promiscuity.

Authors:  Gideon Schreiber; Amy E Keating
Journal:  Curr Opin Struct Biol       Date:  2010-11-09       Impact factor: 6.809

Review 2.  Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.

Authors:  William Hankey; Wendy L Frankel; Joanna Groden
Journal:  Cancer Metastasis Rev       Date:  2018-03       Impact factor: 9.264

3.  Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane.

Authors:  Tianhui Hu; Cunxi Li; Zheng Cao; Terence J Van Raay; Jason G Smith; Karl Willert; Lila Solnica-Krezel; Robert J Coffey
Journal:  J Biol Chem       Date:  2010-02-20       Impact factor: 5.157

Review 4.  Drugging Wnt signalling in cancer.

Authors:  Paul Polakis
Journal:  EMBO J       Date:  2012-05-22       Impact factor: 11.598

5.  Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.

Authors:  Ho-Jin Lee; David Finkelstein; Xiaofeng Li; Dianqing Wu; De-Li Shi; Jie J Zheng
Journal:  J Biol Chem       Date:  2010-11-02       Impact factor: 5.157

6.  Solution structure of the human Tax-interacting protein-1.

Authors:  Michael A Durney; Gabriel Birrane; Clemens Anklin; Aditi Soni; John A A Ladias
Journal:  J Biomol NMR       Date:  2009-08-15       Impact factor: 2.835

Review 7.  Dishevelled: A masterful conductor of complex Wnt signals.

Authors:  Monica Sharma; Isabel Castro-Piedras; Glenn E Simmons; Kevin Pruitt
Journal:  Cell Signal       Date:  2018-03-17       Impact factor: 4.315

Review 8.  WNT signalling pathways as therapeutic targets in cancer.

Authors:  Jamie N Anastas; Randall T Moon
Journal:  Nat Rev Cancer       Date:  2013-01       Impact factor: 60.716

9.  Small molecule modulators of Wnt/β-catenin signaling.

Authors:  Robert A Mook; Minyong Chen; Jiuyi Lu; Larry S Barak; H Kim Lyerly; Wei Chen
Journal:  Bioorg Med Chem Lett       Date:  2013-01-30       Impact factor: 2.823

10.  HSP105 recruits protein phosphatase 2A to dephosphorylate β-catenin.

Authors:  Nancy Yu; Michael Kakunda; Victoria Pham; Jennie R Lill; Pan Du; Matthew Wongchenko; Yibing Yan; Ron Firestein; XiaoDong Huang
Journal:  Mol Cell Biol       Date:  2015-02-02       Impact factor: 4.272
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