Literature DB >> 29559363

Dishevelled: A masterful conductor of complex Wnt signals.

Monica Sharma1, Isabel Castro-Piedras1, Glenn E Simmons2, Kevin Pruitt3.   

Abstract

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1-3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5-10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer; Development; Disease; Dishevelled; Wnt; β-catenin

Mesh：

Substances：

Year:  2018        PMID： 29559363      PMCID： PMC6317740          DOI： 10.1016/j.cellsig.2018.03.004

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  186 in total

1.  Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

Authors:  S Hino; S Kishida; T Michiue; A Fukui; I Sakamoto; S Takada; M Asashima; A Kikuchi
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

Review 2.  The wnt-frizzled cascade in cardiovascular disease.

Authors:  Marielle E van Gijn; Mat J A P Daemen; Jos F M Smits; W Matthijs Blankesteijn
Journal:  Cardiovasc Res       Date:  2002-07       Impact factor: 10.787

3.  Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways.

Authors:  Jean-François Le Garrec; Michel Kerszberg
Journal:  Dev Genes Evol       Date:  2008-07-24       Impact factor: 0.900

4.  Multiple functions of segment polarity genes in Drosophila.

Authors:  N Perrimon; A P Mahowald
Journal:  Dev Biol       Date:  1987-02       Impact factor: 3.582

5.  Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.

Authors:  Andreas Jenny; Jessica Reynolds-Kenneally; Gishnu Das; Micheal Burnett; Marek Mlodzik
Journal:  Nat Cell Biol       Date:  2005-06-05       Impact factor: 28.824

6.  Expression of dishevelled gene in Hirschsprung's disease.

Authors:  Dong Chen; Jie Mi; Mei Wu; Weilin Wang; Hong Gao
Journal:  Int J Clin Exp Pathol       Date:  2013-08-15

7.  Fibroblast growth factor receptor-induced phosphorylation of ephrinB1 modulates its interaction with Dishevelled.

Authors:  Hyun-Shik Lee; Kathleen Mood; Gopala Battu; Yon Ju Ji; Arvinder Singh; Ira O Daar
Journal:  Mol Biol Cell       Date:  2008-11-12       Impact factor: 4.138

8.  Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells.

Authors:  Glenn E Simmons; Somnath Pandey; Ana Nedeljkovic-Kurepa; Madhurima Saxena; Allison Wang; Kevin Pruitt
Journal:  PLoS One       Date:  2014-06-04       Impact factor: 3.240

9.  miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis.

Authors:  Shlomit Kfir-Erenfeld; Noa Haggiag; Moshe Biton; Polina Stepensky; Nathalie Assayag-Asherie; Eitan Yefenof
Journal:  Oncotarget       Date:  2017-01-03

10.  Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.

Authors:  Cen Zhang; Juan Liu; Grace Huang; Yuhan Zhao; Xuetian Yue; Hao Wu; Jun Li; Junlan Zhu; Zhiyuan Shen; Bruce G Haffty; Wenwei Hu; Zhaohui Feng
Journal:  Genes Dev       Date:  2016-09-01       Impact factor: 11.361
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  56 in total

1.  Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.

Authors:  Wakako Kawarazaki; Risuke Mizuno; Mitsuhiro Nishimoto; Nobuhiro Ayuzawa; Daigoro Hirohama; Kohei Ueda; Fumiko Kawakami-Mori; Shigeyoshi Oba; Takeshi Marumo; Toshiro Fujita
Journal:  J Clin Invest       Date:  2020-08-03       Impact factor: 14.808

2.  Signaling network involved in the GPC3-induced inhibition of breast cancer progression: role of canonical Wnt pathway.

Authors:  Dolores Fernández; Macarena Guereño; María Amparo Lago Huvelle; Magalí Cercato; María Giselle Peters
Journal:  J Cancer Res Clin Oncol       Date:  2018-09-28       Impact factor: 4.553

3.  Eph signaling in mitotic spindle orientation: what´s your angle here?

Authors:  Maribel Franco; Ana Carmena
Journal:  Cell Cycle       Date:  2019-09-01       Impact factor: 4.534

4.  Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Authors:  Miroslav Micka; Vítězslav Bryja
Journal:  Handb Exp Pharmacol       Date:  2021

5.  Dishevelled coordinates phosphoinositide kinases PI4KIIIα and PIP5KIγ for efficient PtdInsP2 synthesis.

Authors:  Lizbeth de la Cruz; Raul Riquelme; Oscar Vivas; Andres Barria; Jill B Jensen
Journal:  J Cell Sci       Date:  2022-02-03       Impact factor: 5.285

Review 6.  Inflammatory bowel disease: an overview of Chinese herbal medicine formula-based treatment.

Authors:  Shuo Yuan; Qi Wang; Jiao Li; Jia-Chen Xue; You Li; Huan Meng; Xiao-Ting Hou; Ji-Xing Nan; Qing-Gao Zhang
Journal:  Chin Med       Date:  2022-06-18       Impact factor: 4.546

7.  Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2.

Authors:  Ali Vural; Stephen M Lanier
Journal:  J Cell Sci       Date:  2020-09-04       Impact factor: 5.285

8.  The nanoscale organization of the Wnt signaling integrator Dishevelled in the vegetal cortex domain of an egg and early embryo.

Authors:  John H Henson; Bakary Samasa; Charles B Shuster; Athula H Wikramanayake
Journal:  PLoS One       Date:  2021-05-26       Impact factor: 3.240

9.  Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Authors:  Yan-Hong Cui; Seungwon Yang; Jiangbo Wei; Christopher R Shea; Wen Zhong; Fang Wang; Palak Shah; Muhammad G Kibriya; Xiaolong Cui; Habibul Ahsan; Chuan He; Yu-Ying He
Journal:  Nat Commun       Date:  2021-04-12       Impact factor: 17.694

10.  Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth.

Authors:  Isabel Castro-Piedras; Monica Sharma; Jennifer Brelsfoard; David Vartak; Edgar G Martinez; Cristian Rivera; Deborah Molehin; Robert K Bright; Mohamed Fokar; Josee Guindon; Kevin Pruitt
Journal:  EMBO Rep       Date:  2021-04-16       Impact factor: 9.071
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