Literature DB >> 22617421

Drugging Wnt signalling in cancer.

Paul Polakis1.   

Abstract

Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided.

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Year:  2012        PMID： 22617421      PMCID： PMC3380214          DOI： 10.1038/emboj.2012.126

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  99 in total

1.  The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.

Authors:  Thomas A Graham; Wilson K Clements; David Kimelman; Wenqing Xu
Journal:  Mol Cell       Date:  2002-09       Impact factor: 17.970

2.  The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

Authors:  Marc van de Wetering; Elena Sancho; Cornelis Verweij; Wim de Lau; Irma Oving; Adam Hurlstone; Karin van der Horn; Eduard Batlle; Damien Coudreuse; Anna Pavlina Haramis; Menno Tjon-Pon-Fong; Petra Moerer; Maaike van den Born; Gwen Soete; Steven Pals; Martin Eilers; Rene Medema; Hans Clevers
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

Review 3.  Mutant BRAF melanomas--dependence and resistance.

Authors:  Poulikos I Poulikakos; Neal Rosen
Journal:  Cancer Cell       Date:  2011-01-18       Impact factor: 31.743

4.  Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.

Authors:  Daniel Pinto; Alex Gregorieff; Harry Begthel; Hans Clevers
Journal:  Genes Dev       Date:  2003-07-15       Impact factor: 11.361

5.  Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.

Authors:  Yi Xing; Wilson K Clements; David Kimelman; Wenqing Xu
Journal:  Genes Dev       Date:  2003-11-04       Impact factor: 11.361

6.  Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.

Authors:  Maina Lepourcelet; Ying-Nan P Chen; Dennis S France; Huisheng Wang; Phillip Crews; Frank Petersen; Charles Bruseo; Alexander W Wood; Ramesh A Shivdasani
Journal:  Cancer Cell       Date:  2004-01       Impact factor: 31.743

7.  Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

Authors:  Frank Kuhnert; Corrine R Davis; Hsiao-Ting Wang; Pauline Chu; Mark Lee; Jenny Yuan; Roel Nusse; Calvin J Kuo
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-26       Impact factor: 11.205

Review 8.  Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.

Authors:  Wilson M Clements; Andrew M Lowy; Joanna Groden
Journal:  Clin Colorectal Cancer       Date:  2003-08       Impact factor: 4.481

9.  Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.

Authors:  Laura Lammi; Sirpa Arte; Mirja Somer; Heikki Jarvinen; Paivi Lahermo; Irma Thesleff; Sinikka Pirinen; Pekka Nieminen
Journal:  Am J Hum Genet       Date:  2004-03-23       Impact factor: 11.025

10.  β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

Authors:  Felipe C Geyer; Magali Lacroix-Triki; Kay Savage; Monica Arnedos; Maryou B Lambros; Alan MacKay; Rachael Natrajan; Jorge S Reis-Filho
Journal:  Mod Pathol       Date:  2010-11-12       Impact factor: 7.842
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  103 in total

1.  Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.

Authors:  Shanthi Ganesh; Martin L Koser; Wendy A Cyr; Girish R Chopda; Junyan Tao; Xue Shui; Bo Ying; Dongyu Chen; Purva Pandya; Edmond Chipumuro; Zakir Siddiquee; Kevin Craig; Chengjung Lai; Henryk Dudek; Satdarshan P Monga; Weimin Wang; Bob D Brown; Marc T Abrams
Journal:  Mol Cancer Ther       Date:  2016-07-07       Impact factor: 6.261

Review 2.  Morphogen pathways in systemic sclerosis.

Authors:  Christian Beyer; Jörg H W Distler
Journal:  Curr Rheumatol Rep       Date:  2013-01       Impact factor: 4.592

Review 3.  Can we safely target the WNT pathway?

Authors:  Michael Kahn
Journal:  Nat Rev Drug Discov       Date:  2014-07       Impact factor: 84.694

4.  Epithelial-to-mesenchymal transition and cancer stem cells: emerging targets for novel cancer therapy.

Authors:  M Kwon
Journal:  Cancer Gene Ther       Date:  2014-05       Impact factor: 5.987

5.  Denervation suppresses gastric tumorigenesis.

Authors:  Chun-Mei Zhao; Yoku Hayakawa; Yosuke Kodama; Sureshkumar Muthupalani; Christoph B Westphalen; Gøran T Andersen; Arnar Flatberg; Helene Johannessen; Richard A Friedman; Bernhard W Renz; Arne K Sandvik; Vidar Beisvag; Hiroyuki Tomita; Akira Hara; Michael Quante; Zhishan Li; Michael D Gershon; Kazuhiro Kaneko; James G Fox; Timothy C Wang; Duan Chen
Journal:  Sci Transl Med       Date:  2014-08-20       Impact factor: 17.956

6.  Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.

Authors:  So-Young Hwang; Xianming Deng; Sanguine Byun; Chan Lee; Seung-Joo Lee; Hyunsuk Suh; Jianming Zhang; Qiaofeng Kang; Ting Zhang; Kenneth D Westover; Anna Mandinova; Sam W Lee
Journal:  Cell Rep       Date:  2016-06-16       Impact factor: 9.423

7.  Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.

Authors:  Wenyan Lu; Cuihong Lin; Yonghe Li
Journal:  Cell Signal       Date:  2014-03-06       Impact factor: 4.315

Review 8.  CBP/Catenin antagonists: Targeting LSCs' Achilles heel.

Authors:  Yong-Mi Kim; Eun-Ji Gang; Michael Kahn
Journal:  Exp Hematol       Date:  2017-05-04       Impact factor: 3.084

9.  Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.

Authors:  Obinna N Obianom; Yong Ai; Yingjun Li; Wei Yang; Dong Guo; Hong Yang; Srilatha Sakamuru; Menghang Xia; Fengtian Xue; Yan Shu
Journal:  J Med Chem       Date:  2019-01-10       Impact factor: 7.446

10.  Inhibition by chondroitin sulfate E can specify functional Wnt/β-catenin signaling thresholds in NIH3T3 fibroblasts.

Authors:  Catherine M Willis; Michael Klüppel
Journal:  J Biol Chem       Date:  2012-08-22       Impact factor: 5.157
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