Literature DB >> 18180158

Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.

Neeraj Mahindroo1, Chandanamali Punchihewa, Allison M Bail, Naoaki Fujii.   

Abstract

We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcription activated by exogenous Dvl via the biochemical antagonism. We confirmed tumor cell-selective activation of caspases by these compounds.

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Year:  2007        PMID： 18180158     DOI： 10.1016/j.bmcl.2007.12.039

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.

Authors:  Guillermo Romero; Mark von Zastrow; Peter A Friedman
Journal:  Adv Pharmacol       Date:  2011

2.  Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.

Authors:  Daniele V F Tauriello; Ingrid Jordens; Katharina Kirchner; Jerry W Slootstra; Tom Kruitwagen; Britta A M Bouwman; Maria Noutsou; Stefan G D Rüdiger; Klaus Schwamborn; Alexandra Schambony; Madelon M Maurice
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-12       Impact factor: 11.205

Review 3.  Dishevelled: A masterful conductor of complex Wnt signals.

Authors:  Monica Sharma; Isabel Castro-Piedras; Glenn E Simmons; Kevin Pruitt
Journal:  Cell Signal       Date:  2018-03-17       Impact factor: 4.315

4.  Inhibition of Wnt signaling by Dishevelled PDZ peptides.

Authors:  Yingnan Zhang; Brent A Appleton; Christian Wiesmann; Ted Lau; Mike Costa; Rami N Hannoush; Sachdev S Sidhu
Journal:  Nat Chem Biol       Date:  2009-03-01       Impact factor: 15.040

Review 5.  PDZ Domains as Drug Targets.

Authors:  Nikolaj R Christensen; Jelena Čalyševa; Eduardo F A Fernandes; Susanne Lüchow; Louise S Clemmensen; Linda M Haugaard-Kedström; Kristian Strømgaard
Journal:  Adv Ther (Weinh)       Date:  2019-04-24

6.  CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.

Authors:  Sehee Choi; Hyun-Yi Kim; Pu-Hyeon Cha; Seol Hwa Seo; Chulho Lee; Yejoo Choi; Wookjin Shin; Yunseok Heo; Gyoonhee Han; Weontae Lee; Kang-Yell Choi
Journal:  Life Sci Alliance       Date:  2019-04-10

Review 7.  Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer.

Authors:  Caterina Nardella; Lorenzo Visconti; Francesca Malagrinò; Livia Pagano; Marianna Bufano; Marianna Nalli; Antonio Coluccia; Giuseppe La Regina; Romano Silvestri; Stefano Gianni; Angelo Toto
Journal:  Biol Direct       Date:  2021-10-12       Impact factor: 4.540

8.  Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain.

Authors:  Amy O Stevens; Samuel Luo; Yi He
Journal:  Cells       Date:  2022-08-07       Impact factor: 7.666

9.  Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy.

Authors:  Hyun-Yi Kim; Sehee Choi; Ji-Hye Yoon; Hwan Jung Lim; Hyuk Lee; Jiwon Choi; Eun Ji Ro; Jung-Nyoung Heo; Weontae Lee; Kyoung Tai No; Kang-Yell Choi
Journal:  EMBO Mol Med       Date:  2016-04-01       Impact factor: 12.137
  9 in total

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