OBJECTIVE: This study examined quantitative heel ultrasonography (QUS), 25-hydroxyvitamin D (25-OHD) levels, and urine amino-terminal cross-linking telopeptide of type I collagen (NTX-I) levels in patients with a recent osteoporotic hip fracture to see whether they were clinically useful. METHODS: Stiffness index (SI) T scores from QUS, 25-OHD levels, and urine NTX-I levels were obtained in 53 female and 32 male patients with hip fractures. Sixty-five female patients and 5 male patients attending our geriatric clinic were used for comparison. RESULTS: The SI T scores of the hip fracture patients were less than those of the geriatric clinic patients. The difference was significant in female patients (P= .0001) but not in male patients (P= .1). Serum levels of 25-OHD were less than 28 ng/mL in 50 of 59 patients and less than 5 ng/mL in 2 patients. Levels of urine NTX-I were variable and were not correlated with other parameters. CONCLUSIONS: Patients who have had a hip fracture have a low SI determined by QUS; this is easy to perform, and it provides a baseline T score from which to assess treatment effects. Most of these patients are vitamin D deficient, and measurement of the 25-OHD level would enable physicians to prescribe an appropriate dose of vitamin D. Urine NTX-I measured shortly after a hip fracture is not clinically helpful.
OBJECTIVE: This study examined quantitative heel ultrasonography (QUS), 25-hydroxyvitamin D (25-OHD) levels, and urine amino-terminal cross-linking telopeptide of type I collagen (NTX-I) levels in patients with a recent osteoporotic hip fracture to see whether they were clinically useful. METHODS: Stiffness index (SI) T scores from QUS, 25-OHD levels, and urine NTX-I levels were obtained in 53 female and 32 male patients with hip fractures. Sixty-five female patients and 5 male patients attending our geriatric clinic were used for comparison. RESULTS: The SI T scores of the hip fracture patients were less than those of the geriatric clinic patients. The difference was significant in female patients (P= .0001) but not in male patients (P= .1). Serum levels of 25-OHD were less than 28 ng/mL in 50 of 59 patients and less than 5 ng/mL in 2 patients. Levels of urine NTX-I were variable and were not correlated with other parameters. CONCLUSIONS: Patients who have had a hip fracture have a low SI determined by QUS; this is easy to perform, and it provides a baseline T score from which to assess treatment effects. Most of these patients are vitamin D deficient, and measurement of the 25-OHD level would enable physicians to prescribe an appropriate dose of vitamin D. Urine NTX-I measured shortly after a hip fracture is not clinically helpful.
Authors: P Garnero; E Hausherr; M C Chapuy; C Marcelli; H Grandjean; C Muller; C Cormier; G Bréart; P J Meunier; P D Delmas Journal: J Bone Miner Res Date: 1996-10 Impact factor: 6.741
Authors: D Hans; P Dargent-Molina; A M Schott; J L Sebert; C Cormier; P O Kotzki; P D Delmas; J M Pouilles; G Breart; P J Meunier Journal: Lancet Date: 1996-08-24 Impact factor: 79.321
Authors: M C Chapuy; M E Arlot; F Duboeuf; J Brun; B Crouzet; S Arnaud; P D Delmas; P J Meunier Journal: N Engl J Med Date: 1992-12-03 Impact factor: 91.245