Literature DB >> 1923755

The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein.

F Estruch1.   

Abstract

I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonine content, suggesting that RGM1 and Egr proteins could have functional similarities.

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Year:  1991        PMID： 1923755      PMCID： PMC328782          DOI： 10.1093/nar/19.18.4873

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  31 in total

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Authors:  N Mermod; E A O'Neill; T J Kelly; R Tjian
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Authors:  A J Courey; R Tjian
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Authors:  P Chavrier; M Zerial; P Lemaire; J Almendral; R Bravo; P Charnay
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Authors:  D J Stillman; A T Bankier; A Seddon; E G Groenhout; K A Nasmyth
Journal:  EMBO J       Date:  1988-02       Impact factor: 11.598
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  13 in total

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8.  Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides.

Authors:  R H Proctor; T M Hohn; S P McCormick; A E Desjardins
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9.  Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae.

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10.  Two different, adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans.

Authors:  B Cubero; C Scazzocchio
Journal:  EMBO J       Date:  1994-01-15       Impact factor: 11.598
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