Literature DB >> 19177172

Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

Erik C B Johnson1, Stephen B H Kent.   

Abstract

Modification of a peptide-(α)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(α)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation.

Entities:  

Year:  2007        PMID： 19177172      PMCID： PMC2631171          DOI： 10.1016/j.tetlet.2007.01.030

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  28 in total

1.  High-yield synthesis and purification of an alpha-helical transmembrane domain.

Authors:  L E Fisher; D M Engelman
Journal:  Anal Biochem       Date:  2001-06-01       Impact factor: 3.365

Review 2.  Synthesis of native proteins by chemical ligation.

Authors:  P E Dawson; S B Kent
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

Review 3.  Membrane protein structural biology: the high throughput challenge.

Authors:  Patrick J Loll
Journal:  J Struct Biol       Date:  2003-04       Impact factor: 2.867

4.  Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis.

Authors:  Gerd G Kochendoerfer; David H Jones; Sangwon Lee; Myrta Oblatt-Montal; Stanley J Opella; Mauricio Montal
Journal:  J Am Chem Soc       Date:  2004-03-03       Impact factor: 15.419

5.  Escherichia coli diacylglycerol kinase is an alpha-helical polytopic membrane protein and can spontaneously insert into preformed lipid vesicles.

Authors:  C R Sanders; L Czerski; O Vinogradova; P Badola; D Song; S O Smith
Journal:  Biochemistry       Date:  1996-07-02       Impact factor: 3.162

6.  Simple procedure for reversed-phase high-performance liquid chromatographic purification of long hydrophobic peptides that form transmembrane helices.

Authors:  S Lew; E London
Journal:  Anal Biochem       Date:  1997-08-15       Impact factor: 3.365

7.  sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis.

Authors:  C R Loomis; J P Walsh; R M Bell
Journal:  J Biol Chem       Date:  1985-04-10       Impact factor: 5.157

8.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

9.  Polar residue tagging of transmembrane peptides.

Authors:  Roman A Melnyk; Anthony W Partridge; Jeannie Yip; Yanqiu Wu; Natalie K Goto; Charles M Deber
Journal:  Biopolymers       Date:  2003       Impact factor: 2.505

10.  Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis.

Authors:  Daniel Clayton; George Shapovalov; Joshua A Maurer; Dennis A Dougherty; Henry A Lester; Gerd G Kochendoerfer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-23       Impact factor: 11.205
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  17 in total

1.  Chemical synthesis of membrane proteins by the removable backbone modification method.

Authors:  Shan Tang; Chao Zuo; Dong-Liang Huang; Xiao-Ying Cai; Long-Hua Zhang; Chang-Lin Tian; Ji-Shen Zheng; Lei Liu
Journal:  Nat Protoc       Date:  2017-11-16       Impact factor: 13.491

2.  Rational development of a strategy for modifying the aggregatibility of proteins.

Authors:  Zhongping Tan; Shiying Shang; Samuel J Danishefsky
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

3.  Protein thioester synthesis enabled by sortase.

Authors:  Jingjing J Ling; Rocco L Policarpo; Amy E Rabideau; Xiaoli Liao; Bradley L Pentelute
Journal:  J Am Chem Soc       Date:  2012-06-19       Impact factor: 15.419

4.  A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis.

Authors:  Michael T Jacobsen; Mark E Petersen; Xiang Ye; Mathieu Galibert; George H Lorimer; Vincent Aucagne; Michael S Kay
Journal:  J Am Chem Soc       Date:  2016-09-01       Impact factor: 15.419

5.  Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.

Authors:  Saketh Chemuru; Ravindra Kodali; Ronald Wetzel
Journal:  Biopolymers       Date:  2014-03       Impact factor: 2.505

Review 6.  Aligator: A computational tool for optimizing total chemical synthesis of large proteins.

Authors:  Michael T Jacobsen; Patrick W Erickson; Michael S Kay
Journal:  Bioorg Med Chem       Date:  2017-06-03       Impact factor: 3.641

7.  Total Chemical Synthesis of Human Thyroid-Stimulating Hormone (hTSH) β-Subunit: Application of Arginine-tagged Acetamidomethyl (AcmR) Protecting Groups.

Authors:  John A Brailsford; Jennifer L Stockdill; Abram J Axelrod; Michael T Peterson; Paul A Vadola; Eric V Johnston; Samuel J Danishefsky
Journal:  Tetrahedron       Date:  2018-03-06       Impact factor: 2.457

8.  δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity.

Authors:  Steve Peigneur; Marianne Paolini-Bertrand; Hubert Gaertner; Daniel Biass; Aude Violette; Reto Stöcklin; Philippe Favreau; Jan Tytgat; Oliver Hartley
Journal:  J Biol Chem       Date:  2014-10-28       Impact factor: 5.157

9.  Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

Authors:  Youhei Sohma; Qing-xin Hua; Ming Liu; Nelson B Phillips; Shi-Quan Hu; Jonathan Whittaker; Linda J Whittaker; Aubree Ng; Charles T Roberts; Peter Arvan; Stephen B H Kent; Michael A Weiss
Journal:  J Biol Chem       Date:  2009-12-03       Impact factor: 5.157

10.  Total chemical synthesis of dengue 2 virus capsid protein via native chemical ligation: role of the conserved salt-bridge.

Authors:  Changyou Zhan; Le Zhao; Xishan Chen; Wei-Yue Lu; Wuyuan Lu
Journal:  Bioorg Med Chem       Date:  2013-04-24       Impact factor: 3.641
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