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Literature DB >> 19170493

Gene regulation with polyvalent siRNA-nanoparticle conjugates.

David A Giljohann¹, Dwight S Seferos, Andrew E Prigodich, Pinal C Patel, Chad A Mirkin.

Abstract

We report the synthesis and characterization of polyvalent RNA-gold nanoparticle conjugates (RNA-Au NPs), nanoparticles that are densely functionalized with synthetic RNA oligonucleotides and designed to function in the RNAi pathway. The particles were rationally designed and synthesized to be free of degrading enzymes, have a high surface loading of siRNA duplexes, and contain an auxiliary passivating agent for increased stability in biological media. The resultant conjugates have a half-life six times longer than that of free dsRNA, readily enter cells without the use of transfection agents, and demonstrate a high gene knockdown capability in a cell model.

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Year: 2009 PMID： 19170493 PMCID： PMC2843496 DOI： 10.1021/ja808719p

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

25 in total

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6. A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles.

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9. Evaluation of surface-enhanced resonance Raman scattering for quantitative DNA analysis.

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10. What controls the melting properties of DNA-linked gold nanoparticle assemblies?

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182 in total

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2. Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs.

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6. Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation.

Authors: Dan Zheng; David A Giljohann; David L Chen; Matthew D Massich; Xiao-Qi Wang; Hristo Iordanov; Chad A Mirkin; Amy S Paller
Journal: Proc Natl Acad Sci U S A Date: 2012-07-06 Impact factor: 11.205

7. Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.

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