Literature DB >> 18614389

Chemically modified siRNA: tools and applications.

Jonathan K Watts1, Glen F Deleavey, Masad J Damha.   

Abstract

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.

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Year:  2008        PMID： 18614389     DOI： 10.1016/j.drudis.2008.05.007

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  131 in total

1.  Synthesis of N2-alkyl-8-oxo-7,8-dihydro-2'-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability.

Authors:  Arunkumar Kannan; Cynthia J Burrows
Journal:  J Org Chem       Date:  2010-12-30       Impact factor: 4.354

2.  Monomers for preparation of amide linked RNA: Synthesis of C3'-homologated nucleoside amino acids from d-xylose.

Authors:  Paul Tanui; Martin Kullberg; Ni Song; Yashodhan Chivate; Eriks Rozners
Journal:  Tetrahedron       Date:  2010-07-01       Impact factor: 2.457

3.  Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Authors:  Armando R Hernández; Larryn W Peterson; Eric T Kool
Journal:  ACS Chem Biol       Date:  2012-06-12       Impact factor: 5.100

Review 4.  Polymeric nucleic acid carriers: current issues and novel design approaches.

Authors:  Han Chang Kang; Kang Moo Huh; You Han Bae
Journal:  J Control Release       Date:  2012-07-04       Impact factor: 9.776

Review 5.  DNA nanotechnology from the test tube to the cell.

Authors:  Yuan-Jyue Chen; Benjamin Groves; Richard A Muscat; Georg Seelig
Journal:  Nat Nanotechnol       Date:  2015-09       Impact factor: 39.213

Review 6.  Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

Authors:  Maria Moccia; Mauro F A Adamo; Michele Saviano
Journal:  Artif DNA PNA XNA       Date:  2016-01-11

Review 7.  Silencing disease genes in the laboratory and the clinic.

Authors:  Jonathan K Watts; David R Corey
Journal:  J Pathol       Date:  2011-11-09       Impact factor: 7.996

Review 8.  Oligonucleotide therapeutic approaches for Huntington disease.

Authors:  Dinah W Y Sah; Neil Aronin
Journal:  J Clin Invest       Date:  2011-02-01       Impact factor: 14.808

9.  Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Authors:  Uday Ghanty; Erik Fostvedt; Rachel Valenzuela; Peter A Beal; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

10.  Gene regulation with polyvalent siRNA-nanoparticle conjugates.

Authors:  David A Giljohann; Dwight S Seferos; Andrew E Prigodich; Pinal C Patel; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2009-02-18       Impact factor: 15.419
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