| Literature DB >> 19166292 |
Jaeheon Lee1, John McIntosh, Brian J Hathaway, Eric W Schmidt.
Abstract
Small N-C terminally cyclic ribosomal peptides are common in nature, yet the mechanisms underlying their biosyntheses remain largely unknown. We recently identified candidate peptide cyclase genes in the metagenomes of marine animals. Here we report that PatG, a protease discovered in this analysis, cleaves variables, short peptides out of a precursor protein, and cyclizes these peptides in vivo and in vitro.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19166292 PMCID： PMC2645028 DOI： 10.1021/ja8092168
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419