Literature DB >> 19844642

Metagenomic approaches to natural products from free-living and symbiotic organisms.

Sean F Brady1, Luke Simmons, Jeffrey H Kim, Eric W Schmidt.   

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Year:  2009        PMID: 19844642      PMCID: PMC2919151          DOI: 10.1039/b817078a

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN: 0265-0568            Impact factor:   13.423


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4.  Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.

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Review 5.  Naturally occurring isocyanides.

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6.  Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate.

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7.  Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting.

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8.  Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.

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9.  Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis.

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3.  Microbial genome mining answers longstanding biosynthetic questions.

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Review 4.  Merging chemical ecology with bacterial genome mining for secondary metabolite discovery.

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Review 5.  Natural product discovery from the human microbiome.

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Review 6.  Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

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Review 7.  Natural products: a continuing source of novel drug leads.

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8.  Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.

Authors:  Louis J Cohen; Hahk-Soo Kang; John Chu; Yun-Han Huang; Emma A Gordon; Boojala Vijay B Reddy; Melinda A Ternei; Jeffrey W Craig; Sean F Brady
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9.  Coping with antibiotic resistance: contributions from genomics.

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Review 10.  Marine genomics: at the interface of marine microbial ecology and biodiscovery.

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