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Literature DB >> 18425112

A global assembly line for cyanobactins.

Mohamed S Donia¹, Jacques Ravel, Eric W Schmidt.

Abstract

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

Entities: Chemical Species

Mesh：

Substances：
Peptides, Cyclic

Year: 2008 PMID： 18425112 PMCID： PMC2862271 DOI： 10.1038/nchembio.84

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

11 in total

1. Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence.

Authors: Sebastian Sudek; Margo G Haygood; Diaa T A Youssef; Eric W Schmidt
Journal: Appl Environ Microbiol Date: 2006-06 Impact factor: 4.792

2. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.

Authors: Y M Li; J C Milne; L L Madison; R Kolter; C T Walsh
Journal: Science Date: 1996-11-15 Impact factor: 47.728

3. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.

Authors: Eric W Schmidt; James T Nelson; David A Rasko; Sebastian Sudek; Jonathan A Eisen; Margo G Haygood; Jacques Ravel
Journal: Proc Natl Acad Sci U S A Date: 2005-05-09 Impact factor: 11.205

Review 4. Bioactive natural products from marine cyanobacteria for drug discovery.

Authors: Lik Tong Tan
Journal: Phytochemistry Date: 2007-03-02 Impact factor: 4.072

5. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.

Authors: Mohamed S Donia; Brian J Hathaway; Sebastian Sudek; Margo G Haygood; M J Rosovitz; Jacques Ravel; Eric W Schmidt
Journal: Nat Chem Biol Date: 2006-11-05 Impact factor: 15.040

6. Solution structure of the antitumor candidate trunkamide A by 2D NMR and restrained simulated annealing methods.

Authors: Xavier Salvatella; Josep Maria Caba; Fernando Albericio; Ernest Giralt
Journal: J Org Chem Date: 2003-01-24 Impact factor: 4.354

7. New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella.

Authors: B M Degnan; C J Hawkins; M F Lavin; E J McCaffrey; D L Parry; A L van den Brenk; D J Watters
Journal: J Med Chem Date: 1989-06 Impact factor: 7.446

8. Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue.

Authors: R Banker; S Carmeli
Journal: J Nat Prod Date: 1998-10 Impact factor: 4.050

9. Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa.

Authors: Nadine Ziemert; Keishi Ishida; Philippe Quillardet; Christiane Bouchier; Christian Hertweck; Nicole Tandeau de Marsac; Elke Dittmann
Journal: Appl Environ Microbiol Date: 2008-02-01 Impact factor: 4.792

10. Spontaneity in the patellamide biosynthetic pathway.

Authors: Bruce F Milne; Paul F Long; Antonio Starcevic; Daslav Hranueli; Marcel Jaspars
Journal: Org Biomol Chem Date: 2006-01-09 Impact factor: 3.876

128 in total

1. Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase.

Authors: Joel O Melby; Kyle L Dunbar; Nhat Q Trinh; Douglas A Mitchell
Journal: J Am Chem Soc Date: 2012-03-08 Impact factor: 15.419

2. Linking chemistry and genetics in the growing cyanobactin natural products family.

Authors: Mohamed S Donia; Eric W Schmidt
Journal: Chem Biol Date: 2011-04-22

3. Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.

Authors: Kerstin Engelhardt; Kristin F Degnes; Sergey B Zotchev
Journal: Appl Environ Microbiol Date: 2010-09-17 Impact factor: 4.792

Review 4. Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants.

Authors: Ocky K Radjasa; Yvette M Vaske; Gabriel Navarro; Hélène C Vervoort; Karen Tenney; Roger G Linington; Phillip Crews
Journal: Bioorg Med Chem Date: 2011-07-26 Impact factor: 3.641

5. Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.

Authors: Katie J Molohon; Joel O Melby; Jaeheon Lee; Bradley S Evans; Kyle L Dunbar; Stefanie B Bumpus; Neil L Kelleher; Douglas A Mitchell
Journal: ACS Chem Biol Date: 2011-10-06 Impact factor: 5.100

6. Metabolic model for diversity-generating biosynthesis.

Authors: Ma Diarey Tianero; Elizabeth Pierce; Shrinivasan Raghuraman; Debosmita Sardar; John A McIntosh; John R Heemstra; Zachary Schonrock; Brett C Covington; J Alan Maschek; James E Cox; Brian O Bachmann; Baldomero M Olivera; Duane E Ruffner; Eric W Schmidt
Journal: Proc Natl Acad Sci U S A Date: 2016-02-01 Impact factor: 11.205