Literature DB >> 19156306

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

Jon C Henrikson1, Ashley R Hoover, P Matthew Joyner, Robert H Cichewicz.   

Abstract

A new fungal metabolite, nygerone A (), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

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Year:  2008        PMID： 19156306     DOI： 10.1039/b819208a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  62 in total

1.  Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.

Authors:  Xiaoru Wang; José G Sena Filho; Ashley R Hoover; Jarrod B King; Trevor K Ellis; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

Review 2.  Strategies for mining fungal natural products.

Authors:  Philipp Wiemann; Nancy P Keller
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-22       Impact factor: 3.346

Review 3.  Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.

Authors:  Robert H Cichewicz
Journal:  Nat Prod Rep       Date:  2009-10-27       Impact factor: 13.423

4.  Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation.

Authors:  Jessica C Albright; Matthew T Henke; Alexandra A Soukup; Ryan A McClure; Regan J Thomson; Nancy P Keller; Neil L Kelleher
Journal:  ACS Chem Biol       Date:  2015-04-03       Impact factor: 5.100

Review 5.  Secondary metabolism in fungi: does chromosomal location matter?

Authors:  Jonathan M Palmer; Nancy P Keller
Journal:  Curr Opin Microbiol       Date:  2010-06-02       Impact factor: 7.934

6.  Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.

Authors:  Taro Amagata; Jing Xiao; Yi-Pei Chen; Nicholas Holsopple; Allen G Oliver; Trevor Gokey; Anton B Guliaev; Katsuhiko Minoura
Journal:  J Nat Prod       Date:  2012-11-20       Impact factor: 4.050

7.  Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.

Authors:  L Studt; F J Schmidt; L Jahn; C M K Sieber; L R Connolly; E-M Niehaus; M Freitag; H-U Humpf; B Tudzynski
Journal:  Appl Environ Microbiol       Date:  2013-10-04       Impact factor: 4.792

Review 8.  Unlocking fungal cryptic natural products.

Authors:  Yi-Ming Chiang; Kuan-Han Lee; James F Sanchez; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Commun       Date:  2009-11       Impact factor: 0.986

9.  Restoration of camptothecine production in attenuated endophytic fungus on re-inoculation into host plant and treatment with DNA methyltransferase inhibitor.

Authors:  M M Vasanthakumari; S S Jadhav; Naik Sachin; G Vinod; Singh Shweta; B L Manjunatha; P Mohana Kumara; G Ravikanth; Karaba N Nataraja; R Uma Shaanker
Journal:  World J Microbiol Biotechnol       Date:  2015-08-20       Impact factor: 3.312

Review 10.  Operons.

Authors:  Anne E Osbourn; Ben Field
Journal:  Cell Mol Life Sci       Date:  2009-08-07       Impact factor: 9.261
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