| Literature DB >> 19141469 |
Abstract
The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.Entities:
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Year: 2008 PMID: 19141469 DOI: 10.1101/gad.1759708
Source DB: PubMed Journal: Genes Dev ISSN: 0890-9369 Impact factor: 11.361