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Literature DB >> 19595308

Histone demethylases and cancer.

Sotirios C Kampranis¹, Philip N Tsichlis.

Abstract

Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the role of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2009 PMID： 19595308 PMCID： PMC3505602 DOI： 10.1016/S0065-230X(09)02004-1

Source DB: PubMed Journal: Adv Cancer Res ISSN： 0065-230X Impact factor: 6.242

291 in total

Review 1. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.

Authors: Ali Shilatifard
Journal: Annu Rev Biochem Date: 2006 Impact factor: 23.643

2. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

Authors: Barna D Fodor; Stefan Kubicek; Masato Yonezawa; Roderick J O'Sullivan; Roopsha Sengupta; Laura Perez-Burgos; Susanne Opravil; Karl Mechtler; Gunnar Schotta; Thomas Jenuwein
Journal: Genes Dev Date: 2006-05-31 Impact factor: 11.361

3. Crystal structure and mechanism of human lysine-specific demethylase-1.

Authors: Pete Stavropoulos; Günter Blobel; André Hoelz
Journal: Nat Struct Mol Biol Date: 2006-06-25 Impact factor: 15.369

4. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.

Authors: Min Gyu Lee; Christopher Wynder; Dawn M Schmidt; Dewey G McCafferty; Ramin Shiekhattar
Journal: Chem Biol Date: 2006-06

5. The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer.

Authors: Outi R Saramäki; Teuvo L J Tammela; Paula M Martikainen; Robert L Vessella; Tapio Visakorpi
Journal: Genes Chromosomes Cancer Date: 2006-07 Impact factor: 5.006

6. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.

Authors: Katia Ancelin; Ulrike C Lange; Petra Hajkova; Robert Schneider; Andrew J Bannister; Tony Kouzarides; M Azim Surani
Journal: Nat Cell Biol Date: 2006-05-14 Impact factor: 28.824

7. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

Authors: Johnathan R Whetstine; Amanda Nottke; Fei Lan; Maite Huarte; Sarit Smolikov; Zhongzhou Chen; Eric Spooner; En Li; Gongyi Zhang; Monica Colaiacovo; Yang Shi
Journal: Cell Date: 2006-04-06 Impact factor: 41.582

8. Structural insights into histone demethylation by JMJD2 family members.

Authors: Zhongzhou Chen; Jianye Zang; Johnathan Whetstine; Xia Hong; Foteini Davrazou; Tatiana G Kutateladze; Michael Simpson; Qilong Mao; Cheol-Ho Pan; Shaodong Dai; James Hagman; Kirk Hansen; Yang Shi; Gongyi Zhang
Journal: Cell Date: 2006-05-04 Impact factor: 41.582

9. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

Authors: Xiaobing Shi; Tao Hong; Kay L Walter; Mark Ewalt; Eriko Michishita; Tiffany Hung; Dylan Carney; Pedro Peña; Fei Lan; Mohan R Kaadige; Nicolas Lacoste; Christelle Cayrou; Foteini Davrazou; Anjanabha Saha; Bradley R Cairns; Donald E Ayer; Tatiana G Kutateladze; Yang Shi; Jacques Côté; Katrin F Chua; Or Gozani
Journal: Nature Date: 2006-05-21 Impact factor: 49.962

10. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

Authors: Joanna Wysocka; Tomek Swigut; Hua Xiao; Thomas A Milne; So Yeon Kwon; Joe Landry; Monika Kauer; Alan J Tackett; Brian T Chait; Paul Badenhorst; Carl Wu; C David Allis
Journal: Nature Date: 2006-05-21 Impact factor: 49.962

29 in total

Review 1. Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.

Authors: Gerald V Denis
Journal: Discov Med Date: 2010-12 Impact factor: 2.970

2. ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

Authors: Julie Carnesecchi; Christelle Forcet; Ling Zhang; Violaine Tribollet; Bruno Barenton; Rafik Boudra; Catherine Cerutti; Isabelle M L Billas; Aurélien A Sérandour; Jason S Carroll; Claude Beaudoin; Jean-Marc Vanacker
Journal: Proc Natl Acad Sci U S A Date: 2017-03-27 Impact factor: 11.205

Review 3. Nuclear receptor coregulators as a new paradigm for therapeutic targeting.

Authors: Elaine Y Hsia; Michael L Goodson; June X Zou; Martin L Privalsky; Hong-Wu Chen
Journal: Adv Drug Deliv Rev Date: 2010-10-07 Impact factor: 15.470

Review 4. Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers.

Authors: Aman Kumar; Niti Kumari; Nayudu Nallabelli; Rajendra Prasad
Journal: Indian J Clin Biochem Date: 2019-04-03

5. KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.

Authors: Alexandros Tzatsos; Polina Paskaleva; Francesco Ferrari; Vikram Deshpande; Svetlana Stoykova; Gianmarco Contino; Kwok-Kin Wong; Fei Lan; Patrick Trojer; Peter J Park; Nabeel Bardeesy
Journal: J Clin Invest Date: 2013-01-16 Impact factor: 14.808

Review 6. Lysine-specific histone demethylases in normal and malignant hematopoiesis.

Authors: Jaclyn Andricovich; Yan Kai; Alexandros Tzatsos
Journal: Exp Hematol Date: 2016-05-18 Impact factor: 3.084

7. Integrated genomic analyses identify KDM1A's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer.

Authors: Sathiya Pandi Narayanan; Smriti Singh; Amit Gupta; Sandhya Yadav; Shree Ram Singh; Sanjeev Shukla
Journal: Cancer Lett Date: 2015-07-28 Impact factor: 8.679