| Literature DB >> 19133659 |
Christian Wider1, Justus C Dachsel, Alexandra I Soto, Michael G Heckman, Nancy N Diehl, Mei Yue, Sarah Lincoln, Jan O Aasly, Kristoffer Haugarvoll, John Q Trojanowski, Spiridon Papapetropoulos, Deborah Mash, Alex Rajput, Ali H Rajput, J Mark Gibson, Timothy Lynch, Dennis W Dickson, Ryan J Uitti, Zbigniew K Wszolek, Matthew J Farrer, Owen A Ross.
Abstract
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels. (c) 2009 Movement Disorder Society.Entities:
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Year: 2009 PMID： 19133659 PMCID： PMC2875476 DOI： 10.1002/mds.22442
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338