Literature DB >> 18412265

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.

Owen A Ross1, Yih-Ru Wu, Mei-Ching Lee, Manabu Funayama, Meng-Ling Chen, Alexandra I Soto, Ignacio F Mata, Guey-Jen Lee-Chen, Chiung Mei Chen, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J Farrer, Eng-King Tan, Ruey-Meei Wu.   

Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18412265     DOI： 10.1002/ana.21405

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  83 in total

1.  Lrrk2 p.Q1111H substitution and Parkinson's disease in Latin America.

Authors:  Ignacio F Mata; Greggory J Wilhoite; Dora Yearout; Justin A Bacon; Mario Cornejo-Olivas; Pilar Mazzetti; Victoria Marca; Olimpio Ortega; Oscar Acosta; Carlos Cosentino; Luis Torres; Angel C Medina; Carolina Perez-Pastene; Fernando Díaz-Grez; Carles Vilariño-Güell; Pablo Venegas; Marcelo Miranda; Osvaldo Trujillo-Godoy; Luis Layson; Rodrigo Avello; Elena Dieguez; Victor Raggio; Federico Micheli; Claudia Perandones; Victoria Alvarez; Juan Segura-Aguilar; Matthew J Farrer; Cyrus P Zabetian; Owen A Ross
Journal:  Parkinsonism Relat Disord       Date:  2011-05-31       Impact factor: 4.891

2.  Parkinson's disease in China.

Authors:  You-yong Tian; Cui-ju Tang; Jie Wu; Jun-shan Zhou
Journal:  Neurol Sci       Date:  2010-12-14       Impact factor: 3.307

3.  Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.

Authors:  M Yue; K M Hinkle; P Davies; E Trushina; F C Fiesel; T A Christenson; A S Schroeder; L Zhang; E Bowles; B Behrouz; S J Lincoln; J E Beevers; A J Milnerwood; A Kurti; P J McLean; J D Fryer; W Springer; D W Dickson; M J Farrer; H L Melrose
Journal:  Neurobiol Dis       Date:  2015-03-31       Impact factor: 5.996

4.  Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Authors:  Saurav Brahmachari; Saebom Lee; Sangjune Kim; Changqing Yuan; Senthilkumar S Karuppagounder; Preston Ge; Rosa Shi; Esther J Kim; Alex Liu; Donghoon Kim; Stephan Quintin; Haisong Jiang; Manoj Kumar; Seung Pil Yun; Tae-In Kam; Xiaobo Mao; Yunjong Lee; Deborah A Swing; Lino Tessarollo; Han Seok Ko; Valina L Dawson; Ted M Dawson
Journal:  Brain       Date:  2019-08-01       Impact factor: 13.501

5.  Phactr2 and Parkinson's disease.

Authors:  Christian Wider; Sarah J Lincoln; Michael G Heckman; Nancy N Diehl; Jeremy T Stone; Kristoffer Haugarvoll; Jan O Aasly; J Mark Gibson; Timothy Lynch; Alex Rajput; Michele L Rajput; Ryan J Uitti; Zbigniew K Wszolek; Matthew J Farrer; Owen A Ross
Journal:  Neurosci Lett       Date:  2009-02-10       Impact factor: 3.046

6.  Patient-control association study of the Leucine-Rich repeat kinase 2 (LRRK2) gene in South African Parkinson's disease patients.

Authors:  Soraya Bardien; Janine Blanckenberg; Lize van der Merwe; Matthew J Farrer; Owen A Ross
Journal:  Mov Disord       Date:  2013-09-06       Impact factor: 10.338

Review 7.  The genetics of Parkinson's disease: progress and therapeutic implications.

Authors:  Andrew B Singleton; Matthew J Farrer; Vincenzo Bonifati
Journal:  Mov Disord       Date:  2013-01       Impact factor: 10.338

8.  Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.

Authors:  Owen A Ross; Cleanthe Spanaki; Alida Griffith; Chin-Hsien Lin; Jennifer Kachergus; Kristoffer Haugarvoll; Helen Latsoudis; Andreas Plaitakis; Joaquim J Ferreira; Cristina Sampaio; Vincenzo Bonifati; Ruey-Meei Wu; Cyrus P Zabetian; Matthew J Farrer
Journal:  Parkinsonism Relat Disord       Date:  2008-10-26       Impact factor: 4.891

9.  LRRK2 variation and dementia with Lewy bodies.

Authors:  Michael G Heckman; Alexandra I Soto-Ortolaza; Monica Y Sanchez Contreras; Melissa E Murray; Otto Pedraza; Nancy N Diehl; Ronald Walton; Catherine Labbé; Oswaldo Lorenzo-Betancor; Ryan J Uitti; Jay van Gerpen; Nilüfer Ertekin-Taner; Glenn E Smith; Kejal Kantarci; Rodolfo Savica; David T Jones; Jonathan Graff-Radford; David S Knopman; Val J Lowe; Clifford R Jack; Ronald C Petersen; Joseph E Parisi; Rosa Rademakers; Zbigniew K Wszolek; Neill R Graff-Radford; Tanis J Ferman; Dennis W Dickson; Bradley F Boeve; Owen A Ross
Journal:  Parkinsonism Relat Disord       Date:  2016-07-29       Impact factor: 4.891

10.  Clinical and genetic description of a family with a high prevalence of autosomal dominant restless legs syndrome.

Authors:  Jessica E Young; Carles Vilariño-Güell; Siong-Chi Lin; Zbigniew K Wszolek; Matthew J Farrer
Journal:  Mayo Clin Proc       Date:  2009-02       Impact factor: 7.616
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.