BACKGROUND AND PURPOSE: Development of hemodynamic modifying devices to treat intracranial aneurysms is an active area of research. The asymmetrical vascular stent (AVS), a stent containing a low-porosity patch, is such device. We evaluate AVS efficacy in an in vivo intracranial aneurysm model. METHODS: We created 24 elastase rabbit model aneurysms: 13 treated with the AVS, 5 treated with standard coronary stents, and 6 untreated controls. Four weeks after treatment, aneurysms underwent follow-up angiography, cone-beam micro-CT, histological evaluation, and selective electron microscopy scanning. RESULTS: Four rabbits died early in the study: 3 during AVS treatment and 1 control (secondary to intraprocedural vessel injury and an unrelated tumor, respectively). AVS-treated aneurysms exhibited very weak or no aneurysm flow immediately after treatment and no flow in all aneurysms at follow-up. Standard stent-treated aneurysms showed flow both after treatment (5/5) and at follow-up (3/5). All control aneurysms remained patent during the study. Micro-CT scans showed: 9 of 9 scanned AVS aneurysms were occluded, 6 of 9 AVS were ideally placed, and 3 of 9 low-porosity region partially covered the aneurysm neck; standard stent-treated aneurysms were 1 of 5 occluded, 2 of 5 patent, and 2 of 5 partially patent. Histology results demonstrated: for AVS-treated aneurysms, advanced thrombus organization in the (9/9); for standard stent-treated aneurysms, (1/4) no thrombus, (2/4) partially thrombosed, and (1/4) fully thrombosed; for control aneurysms (4/4), no thrombus. CONCLUSIONS: The use of AVS shows promise as a viable new therapeutic in intracranial aneurysm treatment. These data encourage further investigation and provide substantial support to the AVS concept.
BACKGROUND AND PURPOSE: Development of hemodynamic modifying devices to treat intracranial aneurysms is an active area of research. The asymmetrical vascular stent (AVS), a stent containing a low-porosity patch, is such device. We evaluate AVS efficacy in an in vivo intracranial aneurysm model. METHODS: We created 24 elastase rabbit model aneurysms: 13 treated with the AVS, 5 treated with standard coronary stents, and 6 untreated controls. Four weeks after treatment, aneurysms underwent follow-up angiography, cone-beam micro-CT, histological evaluation, and selective electron microscopy scanning. RESULTS: Four rabbits died early in the study: 3 during AVS treatment and 1 control (secondary to intraprocedural vessel injury and an unrelated tumor, respectively). AVS-treated aneurysms exhibited very weak or no aneurysm flow immediately after treatment and no flow in all aneurysms at follow-up. Standard stent-treated aneurysms showed flow both after treatment (5/5) and at follow-up (3/5). All control aneurysms remained patent during the study. Micro-CT scans showed: 9 of 9 scanned AVSaneurysms were occluded, 6 of 9 AVS were ideally placed, and 3 of 9 low-porosity region partially covered the aneurysm neck; standard stent-treated aneurysms were 1 of 5 occluded, 2 of 5 patent, and 2 of 5 partially patent. Histology results demonstrated: for AVS-treated aneurysms, advanced thrombus organization in the (9/9); for standard stent-treated aneurysms, (1/4) no thrombus, (2/4) partially thrombosed, and (1/4) fully thrombosed; for control aneurysms (4/4), no thrombus. CONCLUSIONS: The use of AVS shows promise as a viable new therapeutic in intracranial aneurysm treatment. These data encourage further investigation and provide substantial support to the AVS concept.
Authors: Ciprian N Ionita; Keneth R Hoffmann; Daniel R Bednarek; Ravishankar Chityala; Stephen Rudin Journal: J Digit Imaging Date: 2007-02-28 Impact factor: 4.056
Authors: Timo Krings; Franz J Hans; Walter Möller-Hartmann; Anna Brunn; Ruth Thiex; Thomas Schmitz-Rode; Peter Verken; Kira Scherer; Heiko Dreeskamp; Klaus P Stein; Joachim Gilsbach; Armin Thron Journal: Neurosurgery Date: 2005-06 Impact factor: 4.654
Authors: C N Ionita; S K Natarajan; W Wang; L N Hopkins; E I Levy; A H Siddiqui; D R Bednarek; S Rudin Journal: AJNR Am J Neuroradiol Date: 2011-07-14 Impact factor: 3.825
Authors: Ciprian N Ionita; Himanshu Suri; Sabareesh Nataranjian; Adnan Siddiqui; Elad Levy; Nelson L Hopkins; Daniel R Bednarek; Stephen Rudin Journal: Proc SPIE Int Soc Opt Eng Date: 2011
Authors: Aradhana Yoganand; Rachel P Wood; Carlos Jimenez; Adnan Siddiqui; Kenneth Snyder; S V Setlur Nagesh; D R Bednarek; S Rudin; Robert Baier; Ciprian N Ionita Journal: Proc SPIE Int Soc Opt Eng Date: 2015-03-17
Authors: Ciprian N Ionita; Andreea Dohatcu; Andrey Sinelnikov; Jason Sherman; Christos Keleshis; Ann M Paciorek; K R Hoffmann; D R Bednarek; S Rudin Journal: Proc SPIE Int Soc Opt Eng Date: 2009-01-01