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Literature DB >> 19130513

Proton-detected solid-state NMR spectroscopy of natural-abundance peptide and protein pharmaceuticals.

Donghua H Zhou¹, Gautam Shah, Charles Mullen, Dennis Sandoz, Chad M Rienstra.

Abstract

The natural way: A sensitive NMR spectroscopic method is developed to obtain well-resolved two-dimensional spectra ((15)N-(1)H and (13)C-(1)H) for natural-abundance (that is, without the need for isotopic enrichment) large-molecule samples, such as biopharmaceuticals. This method gives structural insights on two lyophilized aprotinin samples and three insulin samples in lyophilized, microcrystalline suspension formulation (red; see picture) and fibril (green) forms.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19130513 PMCID： PMC2811381 DOI： 10.1002/anie.200801029

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

23 in total

Review 1. Lyophilization and development of solid protein pharmaceuticals.

Authors: W Wang
Journal: Int J Pharm Date: 2000-08-10 Impact factor: 5.875

Review 2. Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications.

Authors: Patrick A Tishmack; David E Bugay; Stephen R Byrn
Journal: J Pharm Sci Date: 2003-03 Impact factor: 3.534

3. Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy.

Authors: Federica Castellani; Barth van Rossum; Annette Diehl; Mario Schubert; Kristina Rehbein; Hartmut Oschkinat
Journal: Nature Date: 2002-11-07 Impact factor: 49.962

4. Sensitive high resolution inverse detection NMR spectroscopy of proteins in the solid state.

Authors: Eric K Paulson; Corey R Morcombe; Vadim Gaponenko; Barbara Dancheck; R Andrew Byrd; Kurt W Zilm
Journal: J Am Chem Soc Date: 2003-12-24 Impact factor: 15.419

Review 5. Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).

Authors: Andre S Raw; M Scott Furness; Devinder S Gill; Richard C Adams; Frank O Holcombe; Lawrence X Yu
Journal: Adv Drug Deliv Rev Date: 2004-02-23 Impact factor: 15.470

6. Solid-state protein-structure determination with proton-detected triple-resonance 3D magic-angle-spinning NMR spectroscopy.

Authors: Donghua H Zhou; John J Shea; Andrew J Nieuwkoop; W Trent Franks; Benjamin J Wylie; Charles Mullen; Dennis Sandoz; Chad M Rienstra
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

7. High-performance solvent suppression for proton detected solid-state NMR.

Authors: Donghua H Zhou; Chad M Rienstra
Journal: J Magn Reson Date: 2008-02-01 Impact factor: 2.229

8. Rapid analysis of organic compounds by proton-detected heteronuclear correlation NMR spectroscopy with 40 kHz magic-angle spinning.

Authors: Donghua H Zhou; Chad M Rienstra
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

9. Correlation of structural elements and infectivity of the HET-s prion.

Authors: Christiane Ritter; Marie-Lise Maddelein; Ansgar B Siemer; Thorsten Lührs; Matthias Ernst; Beat H Meier; Sven J Saupe; Roland Riek
Journal: Nature Date: 2005-06-09 Impact factor: 49.962

Review 10. Insulin structure and stability.

Authors: J Brange; L Langkjoer
Journal: Pharm Biotechnol Date: 1993

19 in total

1. Proton-evolved local-field solid-state NMR studies of cytochrome b5 embedded in bicelles, revealing both structural and dynamical information.

Authors: Ronald Soong; Pieter E S Smith; Jiadi Xu; Kazutoshi Yamamoto; Sang-Choul Im; Lucy Waskell; Ayyalusamy Ramamoorthy
Journal: J Am Chem Soc Date: 2010-04-28 Impact factor: 15.419

2. Spin diffusion driven by R-symmetry sequences: applications to homonuclear correlation spectroscopy in MAS NMR of biological and organic solids.

Authors: Guangjin Hou; Si Yan; Shangjin Sun; Yun Han; In-Ja L Byeon; Jinwoo Ahn; Jason Concel; Ago Samoson; Angela M Gronenborn; Tatyana Polenova
Journal: J Am Chem Soc Date: 2011-03-01 Impact factor: 15.419

3. Performance of RINEPT is amplified by dipolar couplings under ultrafast MAS conditions.

Authors: Rongchun Zhang; Ayyalusamy Ramamoorthy
Journal: J Magn Reson Date: 2014-04-16 Impact factor: 2.229

4. Finite-pulse radio frequency driven recoupling with phase cycling for 2D (1)H/(1)H correlation at ultrafast MAS frequencies.

Authors: Yusuke Nishiyama; Rongchun Zhang; Ayyalusamy Ramamoorthy
Journal: J Magn Reson Date: 2014-03-20 Impact factor: 2.229

5. Determination of relative tensor orientations by γ-encoded chemical shift anisotropy/heteronuclear dipolar coupling 3D NMR spectroscopy in biological solids.

Authors: Guangjin Hou; Sivakumar Paramasivam; In-Ja L Byeon; Angela M Gronenborn; Tatyana Polenova
Journal: Phys Chem Chem Phys Date: 2010-10-08 Impact factor: 3.676

6. A cross-polarization based rotating-frame separated-local-field NMR experiment under ultrafast MAS conditions.

Authors: Rongchun Zhang; Joshua Damron; Thomas Vosegaard; Ayyalusamy Ramamoorthy
Journal: J Magn Reson Date: 2014-11-15 Impact factor: 2.229

7. Broadband homonuclear correlation spectroscopy driven by combined R2(n)(v) sequences under fast magic angle spinning for NMR structural analysis of organic and biological solids.

Authors: Guangjin Hou; Si Yan; Julien Trébosc; Jean-Paul Amoureux; Tatyana Polenova
Journal: J Magn Reson Date: 2013-04-28 Impact factor: 2.229