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Literature DB >> 19127410

Application of genome-wide SNP data for uncovering pairwise relationships and quantitative trait loci.

Abstract

The genetic analysis of quantitative traits in humans is changing as a result of the availability of whole-genome SNP data. Heritability analysis can make use of actual genetic sharing between pairs of individuals estimated from the genotype data, rather than the expected genetic sharing implied by their family relationship. This could provide more accurate heritability estimates and help to overcome the equal environment assumption. Quantitative trait locus (QTL) linkage mapping can make use of local genetic sharing inferred from very dense local genotype data from pedigree members or individuals not previously known to be related. This approach may be particularly suited for detecting loci that contain rare variants with major effect on the phenotype. Finally, whole-genome SNP data can be used to measure the genetic similarity between individuals to provide matched sets for association studies, in order to avoid spurious association from population stratification.

Entities: Species

Mesh：

Year: 2009 PMID： 19127410 DOI： 10.1007/s10709-008-9349-4

Source DB: PubMed Journal: Genetica ISSN： 0016-6707 Impact factor: 1.082

18 in total

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Authors: Peter M Visscher; Sarah E Medland; Manuel A R Ferreira; Katherine I Morley; Gu Zhu; Belinda K Cornes; Grant W Montgomery; Nicholas G Martin
Journal: PLoS Genet Date: 2006-03-24 Impact factor: 5.917

10 in total

Review 1. Genomics and the future of conservation genetics.

Authors: Fred W Allendorf; Paul A Hohenlohe; Gordon Luikart
Journal: Nat Rev Genet Date: 2010-10 Impact factor: 53.242

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Authors: Emrah Kostem; Eleazar Eskin
Journal: Am J Hum Genet Date: 2013-04-04 Impact factor: 11.025

3. Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix.

Authors: Chao Wang; Yanan You; Hongxia Wang; Baozhong Liu
Journal: Mol Biol Rep Date: 2011-05-20 Impact factor: 2.316

4. Inference of relationships in population data using identity-by-descent and identity-by-state.

Authors: Eric L Stevens; Greg Heckenberg; Elisha D O Roberson; Joseph D Baugher; Thomas J Downey; Jonathan Pevsner
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10. Alternative parameterizations of relatedness in whole genome association analysis of pre-weaning traits of Nelore-Angus calves.

Authors: David G Riley; Clare A Gill; Andy D Herring; Penny K Riggs; Jason E Sawyer; James O Sanders
Journal: Genet Mol Biol Date: 2014-09 Impact factor: 1.771