Wolf-Dieter Heiss1. 1. Max Planck Institute for Neurological Research, Gleueler Str. 50, 50931, Cologne, Germany. wdh@nf.mpg.de
Abstract
INTRODUCTION: The completion of an integrated PET/MR prototype system for brain imaging is the latest step in the evolution of positron emission tomography. Early images with this new imaging system demonstrate that high-resolution multiparametric studies can be combined without significant loss of performance of either imaging modality. OBJECTIVE: This new technology will make fusion of morphological and biological information much easier, yield real-time assessment of complementary variables and will provide dynamic information for kinetic modelling. Simultaneous acquisition of various metabolic and functional parameters may open new insights into the organization of the brain and its changes in disease. DISCUSSION: A new field may open up for molecular and cellular imaging, where new targets--e.g. angiogenesis, gene transfer, function and migration of transplanted cells--can be imaged in the morphological context and within a functional environment. This application might have a special impact on the translation of treatment concepts from experimental models into clinical application. If the added value of the hybrid system for diagnosis and treatment monitoring is established, a cost-effective PET/MR combination might attain wider clinical application.
INTRODUCTION: The completion of an integrated PET/MR prototype system for brain imaging is the latest step in the evolution of positron emission tomography. Early images with this new imaging system demonstrate that high-resolution multiparametric studies can be combined without significant loss of performance of either imaging modality. OBJECTIVE: This new technology will make fusion of morphological and biological information much easier, yield real-time assessment of complementary variables and will provide dynamic information for kinetic modelling. Simultaneous acquisition of various metabolic and functional parameters may open new insights into the organization of the brain and its changes in disease. DISCUSSION: A new field may open up for molecular and cellular imaging, where new targets--e.g. angiogenesis, gene transfer, function and migration of transplanted cells--can be imaged in the morphological context and within a functional environment. This application might have a special impact on the translation of treatment concepts from experimental models into clinical application. If the added value of the hybrid system for diagnosis and treatment monitoring is established, a cost-effective PET/MR combination might attain wider clinical application.
Authors: W D Heiss; K Vyska; G Kloster; H Traupe; C Freundlieb; A Hoeck; L E Feinendegen; G Stoecklin Journal: Neuroradiology Date: 1982 Impact factor: 2.804
Authors: Dale L Bailey; Henryk Barthel; Bettina Beuthin-Baumann; Thomas Beyer; Sotirios Bisdas; Ronald Boellaard; Johannes Czernin; Alexander Drzezga; Ulrike Ernemann; Christiane Franzius; Brigitte Gückel; Rupert Handgretinger; Markus Hartenbach; Dirk Hellwig; Helen Nadel; Stephan G Nekolla; Thomas Pfluger; Bernd J Pichler; Harald H Quick; Osama Sabri; Bernhard Sattler; Jürgen Schäfer; Fritz Schick; Barry A Siegel; Heinz P Schlemmer; Nina F Schwenzer; Jörg van den Hoff; Patrick Veit-Haibach; Hans F Wehrl Journal: Mol Imaging Biol Date: 2014-06 Impact factor: 3.488