Literature DB >> 11328693

Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease.

R Mielke1, H H Schopphoff, H Kugel, U Pietrzyk, W Heindel, J Kessler, W D Heiss.   

Abstract

1 H Magnetic resonance spectroscopic imaging (MRSI) and positron emission tomography (PET) of (18) F-2-fluoro-2-deoxy-D-glucose (FDG) were performed in 18 patients with probable Alzheimer's disease (AD) and 3 normal controls. We measured the distribution and relative signal intensities of N-acetyl aspartate (NAA; a presumed neuronal marker), choline residues (Cho) representing cellular membrane compounds and of creatine-containing metabolites (Cr), and correlated these to regional cerebral glucose metabolism (rCMRGI) after coregistration of both imaging-techniques. The pattern of choline was significantly different between AD and normals (p < 0.01). RCMRGI was significantly related to Cho/Cr (r=-0.21, p<.05) and NAA/Cho quotients (r=0.35, p<.001). Our results suggest that in AD reduced neuronal energy performance and membrane abnormalities contribute to metabolic deterioration.

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Year:  2001        PMID： 11328693     DOI： 10.3109/00207450109150687

Source DB:  PubMed          Journal:  Int J Neurosci        ISSN： 0020-7454            Impact factor:   2.292


  7 in total

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Authors:  Wolf-Dieter Heiss
Journal:  Eur J Nucl Med Mol Imaging       Date:  2009-03       Impact factor: 9.236

2.  Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.

Authors:  Xiaoping Zhu; Norbert Schuff; John Kornak; Brian Soher; Kristine Yaffe; Joel H Kramer; Frank Ezekiel; Bruce L Miller; William J Jagust; Michael W Weiner
Journal:  Alzheimer Dis Assoc Disord       Date:  2006 Apr-Jun       Impact factor: 2.703

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4.  Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex.

Authors:  Nick C Patel; Kim M Cecil; Stephen M Strakowski; Caleb M Adler; Melissa P DelBello
Journal:  J Child Adolesc Psychopharmacol       Date:  2008-12       Impact factor: 2.576

Review 5.  Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease.

Authors:  Steven N Austad; Scott Ballinger; Thomas W Buford; Christy S Carter; Daniel L Smith; Victor Darley-Usmar; Jianhua Zhang
Journal:  Acta Pharm Sin B       Date:  2021-06-30       Impact factor: 11.413

6.  Neuroprotection and neurodegeneration in Alzheimer's disease: role of cardiovascular disease risk factors, implications for dementia rates, and prevention with aerobic exercise in african americans.

Authors:  Thomas O Obisesan; Richard F Gillum; Stephanie Johnson; Nisser Umar; Deborah Williams; Vernon Bond; John Kwagyan
Journal:  Int J Alzheimers Dis       Date:  2012-04-17

7.  Strategies for molecular imaging dementia and neurodegenerative diseases.

Authors:  Bernhard J Schaller
Journal:  Neuropsychiatr Dis Treat       Date:  2008-06       Impact factor: 2.570
  7 in total

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