Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A synthetic lectin for O-linked beta-N-acetylglucosamine.

Literature DB >> 19072969

A synthetic lectin for O-linked beta-N-acetylglucosamine.

Yann Ferrand¹, Emmanuel Klein, Nicholas P Barwell, Matthew P Crump, Jesus Jiménez-Barbero, Cristina Vicent, Geert-Jan Boons, Sampat Ingale, Anthony P Davis.

Abstract

Changing employment: Receptor 1 binds beta-N-acetylglucosaminyl (beta-GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine-O-GlcNAc posttranslational protein modification.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19072969 PMCID： PMC2835298 DOI： 10.1002/anie.200804905

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

24 in total

Review 1. The emerging significance of O-GlcNAc in cellular regulation.

Authors: Natasha E Zachara; Gerald W Hart
Journal: Chem Rev Date: 2002-02 Impact factor: 60.622

2. Precipitation and carbohydrate-binding specificity studies on wheat germ agglutinin.

Authors: I J Goldstein; S Hammarström; G Sundblad
Journal: Biochim Biophys Acta Date: 1975-09-09

Review 3. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress.

Authors: Natasha E Zachara; Gerald W Hart
Journal: Biochim Biophys Acta Date: 2004-07-06

4. The purification, composition and specificity of wheat-germ agglutinin.

Authors: A K Allen; A Neuberger; N Sharon
Journal: Biochem J Date: 1973-01 Impact factor: 3.857

5. Comparative analysis by frontal affinity chromatography of oligosaccharide specificity of GlcNAc-binding lectins, Griffonia simplicifolia lectin-II (GSL-II) and Boletopsis leucomelas lectin (BLL).

Authors: Sachiko Nakamura-Tsuruta; Junko Kominami; Masugu Kamei; Yu Koyama; Takuji Suzuki; Mamoru Isemura; Jun Hirabayashi
Journal: J Biochem Date: 2006-07-11 Impact factor: 3.387

Review 6. Chemical glycobiology.

Authors: C R Bertozzi; L L Kiessling
Journal: Science Date: 2001-03-23 Impact factor: 47.728

7. Molecular recognition of saccharides by proteins. Insights on the origin of the carbohydrate-aromatic interactions.

Authors: María del Carmen Fernández-Alonso; Francisco Javier Cañada; Jesús Jiménez-Barbero; Gabriel Cuevas
Journal: J Am Chem Soc Date: 2005-05-25 Impact factor: 15.419

8. Highly effective acyclic carbohydrate receptors consisting of aminopyridine, imidazole, and indole recognition units.

Authors: Monika Mazik; Matthias Kuschel
Journal: Chemistry Date: 2008 Impact factor: 5.236

Review 9. Chemical biology of the sugar code.

Authors: Hans-Joachim Gabius; Hans-Christian Siebert; Sabine André; Jesús Jiménez-Barbero; Harold Rüdiger
Journal: Chembiochem Date: 2004-06-07 Impact factor: 3.164

A synthetic lectin for O-linked beta-N-acetylglucosamine.

Review 1. The emerging significance of O-GlcNAc in cellular regulation.

2. Precipitation and carbohydrate-binding specificity studies on wheat germ agglutinin.

Review 3. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress.

4. The purification, composition and specificity of wheat-germ agglutinin.

5. Comparative analysis by frontal affinity chromatography of oligosaccharide specificity of GlcNAc-binding lectins, Griffonia simplicifolia lectin-II (GSL-II) and Boletopsis leucomelas lectin (BLL).

Review 6. Chemical glycobiology.

7. Molecular recognition of saccharides by proteins. Insights on the origin of the carbohydrate-aromatic interactions.

8. Highly effective acyclic carbohydrate receptors consisting of aminopyridine, imidazole, and indole recognition units.

Review 9. Chemical biology of the sugar code.

Review 10. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins.

1. A threading receptor for polysaccharides.

Review 2. Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.

3. Carbohydrate recognition: a minimalistic approach to binding.

4. Rapid Macrocycle Threading by a Fluorescent Dye-Polymer Conjugate in Water with Nanomolar Affinity.

5. Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose.

Review 6. Proteomic approaches for site-specific O-GlcNAcylation analysis.

7. Recognition properties of receptors consisting of imidazole and indole recognition units towards carbohydrates.

8. A simple and accessible synthetic lectin for glucose recognition and sensing.

Review 9. Progress in biomimetic carbohydrate recognition.

10. Sensitive Structural Control of Macrocycle Threading by a Fluorescent Squaraine Dye Flanked by Polymer Chains.