Literature DB >> 19023673

A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence.

Ahmad Shaabani1, Ali Maleki, Hamid Mofakham.   

Abstract

By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.

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Year:  2008        PMID： 19023673     DOI： 10.1007/s11030-008-9099-3

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  14 in total

Review 1.  The multicomponent reactions and their libraries for natural and preparative chemistry.

Authors:  I Ugi; S Heck
Journal:  Comb Chem High Throughput Screen       Date:  2001-02       Impact factor: 1.339

2.  Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.

Authors:  D Lee; J K Sello; S L Schreiber
Journal:  Org Lett       Date:  2000-03-09       Impact factor: 6.005

3.  Maximizing synthetic efficiency: multi-component transformations lead the way

Authors: 
Journal:  Chemistry       Date:  2000-09-15       Impact factor: 5.236

4.  Multicomponent Reactions with Isocyanides.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-09-15       Impact factor: 15.336

Review 5.  "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Authors:  Christopher Hulme; Vijay Gore
Journal:  Curr Med Chem       Date:  2003-01       Impact factor: 4.530

6.  A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives.

Authors:  Ahmad Shaabani; Ali Maleki; Jafar Moghimi-Rad
Journal:  J Org Chem       Date:  2007-07-04       Impact factor: 4.354

7.  Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands.

Authors:  Richard A Hartz; Paul J Gilligan; Kausik K Nanda; Andrew J Tebben; Larry W Fitzgerald; Keith Miller
Journal:  Bioorg Med Chem Lett       Date:  2002-02-11       Impact factor: 2.823

8.  Novel isocyanide-based three-component synthesis of 3,4-dihydroquinoxalin-2-amine derivatives.

Authors:  Ahmad Shaabani; Ali Maleki; Hamid Mofakham; Hamid Reza Khavasi
Journal:  J Comb Chem       Date:  2008-02-01

9.  Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence.

Authors:  Barbara Beck; Anne Picard; Eberhardt Herdtweck; Alexander Dömling
Journal:  Org Lett       Date:  2004-01-08       Impact factor: 6.005

10.  Novel multicomponent one-pot synthesis of tetrahydro-1H-1,5-benzodiazepine-2-carboxamide derivatives.

Authors:  Ahmad Shaabani; Ali Maleki; Hamid Mofakham
Journal:  J Comb Chem       Date:  2008-06-14
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  4 in total

Review 1.  Recent progress of isocyanide-based multicomponent reactions in Iran.

Authors:  Ahmad Shaabani; Ali Maleki; Ali Hossein Rezayan; Afshin Sarvary
Journal:  Mol Divers       Date:  2010-07-29       Impact factor: 2.943

2.  [Hmim]TFA catalyzed multicomponent reaction: direct, mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives.

Authors:  Minoo Dabiri; Mahboobeh Bahramnejad; Sahareh Bashiribod
Journal:  Mol Divers       Date:  2010-01-29       Impact factor: 2.943

3.  A new one-pot three-component synthesis of 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitrile derivatives.

Authors:  Ahmad Shaabani; Fatemeh Hajishaabanha; Hamid Mofakham; Ali Maleki
Journal:  Mol Divers       Date:  2009-05-16       Impact factor: 2.943

4.  Combined isocyanide-based multi-component Ullmann-type reaction: an efficient access to novel nitrogen-containing pentacyclic compounds.

Authors:  Shima Dianat; Mohammad Mahdavi; Setareh Moghimi; Arash Mouradzadegun; Abbas Shafiee; Alireza Foroumadi
Journal:  Mol Divers       Date:  2015-08-01       Impact factor: 2.943
  4 in total

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