| Literature DB >> 19008020 |
Kamaljit Singh1, Divya Arora, Elizabeth Poremsky, Jazmyne Lowery, Robert S Moreland.
Abstract
It has been found that selective N1-alkylation of 3,4-dihydropyrimidine-2(1H)-ones can be achieved under solvent-less, mild phase transfer catalytic (PTC) conditions with tetrabutylammonium hydrogen sulfate and 50% aqueous NaOH as the catalyst and base, respectively. The procedure is tolerant to substitutional variation at key diversity points on the pyrimidinone moiety.Entities:
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Year: 2008 PMID： 19008020 DOI： 10.1016/j.ejmech.2008.10.002
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514