Literature DB >> 21749159

Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.

Lauren E Brown1, Peng Dai, John A Porco, Scott E Schaus.   

Abstract

Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones.
© 2011 American Chemical Society

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Year:  2011        PMID： 21749159      PMCID： PMC4251731          DOI： 10.1021/ol2015658

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  35 in total

1.  Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones.

Authors:  Paul W Davies; Christelle Detty-Mambo
Journal:  Org Biomol Chem       Date:  2010-05-25       Impact factor: 3.876

2.  Gold(III)-catalyzed nucleophilic substitution of propargylic alcohols.

Authors:  Marie Georgy; Valérie Boucard; Jean-Marc Campagne
Journal:  J Am Chem Soc       Date:  2005-10-19       Impact factor: 15.419

Review 3.  Relativistic effects in homogeneous gold catalysis.

Authors:  David J Gorin; F Dean Toste
Journal:  Nature       Date:  2007-03-22       Impact factor: 49.962

4.  Combining the concepts: dual catalysis with carbophilic Lewis acids.

Authors:  Alexander Duschek; Stefan F Kirsch
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

5.  Addition of metal enolate derivatives to unactivated carbon-carbon multiple bonds.

Authors:  Fabrice Dénès; Alejandro Pérez-Luna; Fabrice Chemla
Journal:  Chem Rev       Date:  2010-04-14       Impact factor: 60.622

6.  Gold-catalyzed tandem cycloisomerization-hydroalkoxylation of homopropargylic alcohols.

Authors:  Volker Belting; Norbert Krause
Journal:  Org Lett       Date:  2006-09-28       Impact factor: 6.005

7.  Combination iminium, enamine and copper(I) cascade catalysis: a carboannulation for the synthesis of cyclopentenes.

Authors:  Ting Yang; Alessandro Ferrali; Leonie Campbell; Darren J Dixon
Journal:  Chem Commun (Camb)       Date:  2008-04-21       Impact factor: 6.222

8.  Microwave-assisted scavenging of electrophiles utilizing polymer-supported sequestration reagents. Application to the synthesis of N3-acylated dihydropyrimidine libraries.

Authors:  Doris Dallinger; Nikolay Yu Gorobets; C Oliver Kappe
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

9.  Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes.

Authors:  Ellen C Minnihan; Steven L Colletti; F Dean Toste; Hong C Shen
Journal:  J Org Chem       Date:  2007-07-11       Impact factor: 4.354

10.  N1-Alkylated 3,4-dihydropyrimidine-2(1H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity.

Authors:  Kamaljit Singh; Divya Arora; Elizabeth Poremsky; Jazmyne Lowery; Robert S Moreland
Journal:  Eur J Med Chem       Date:  2008-10-11       Impact factor: 6.514
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  3 in total

1.  Assembly of four diverse heterocyclic libraries enabled by Prins cyclization, Au-catalyzed enyne cycloisomerization, and automated amide synthesis.

Authors:  Jiayue Cui; David I Chai; Christopher Miller; Jason Hao; Christopher Thomas; JingQi Wang; Karl A Scheidt; Sergey A Kozmin
Journal:  J Org Chem       Date:  2012-08-16       Impact factor: 4.354

2.  Copper (triazole-5-yl)methanamine complexes onto MCM-41: the synthesis of pyridine-containing pseudopeptides through the 6-endo-dig cyclization of 1,5-enynes.

Authors:  Neda Akbarikalani; Kamran Amiri; Ahmed Al-Harrasi; Saeed Balalaie
Journal:  RSC Adv       Date:  2020-03-12       Impact factor: 4.036

3.  Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity.

Authors:  Ruth Dorel; Antonio M Echavarren
Journal:  Chem Rev       Date:  2015-04-06       Impact factor: 60.622
  3 in total

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