Literature DB >> 23960779

Synthesis, characterization and biological evaluation of dihydropyrimidine derivatives.

Adithya Adhikari1, Balakrishna Kalluraya, K V Sujith, Riaz Mahmood.   

Abstract

A series of dihydropyrimidines containing quinoline were prepared under conventional heating and microwave irradiation. The structures of newly synthesized compounds were established based on analytical and spectral studies. Further these compounds were evaluated for their antioxidant, antifungal and antibacterial activities. Most of the compounds showed moderate to good activity when compared with standard.

Entities:  

Keywords:  Antibacterial activity; Antifungal activity; Antioxidant activity; MW assisted synthesis; Quinolinodihydropyrimidines; Three component reaction

Year:  2011        PMID: 23960779      PMCID: PMC3744957          DOI: 10.1016/j.jsps.2011.04.002

Source DB:  PubMed          Journal:  Saudi Pharm J        ISSN: 1319-0164            Impact factor:   4.330


  12 in total

1.  Microwave-assisted high-speed chemistry: a new technique in drug discovery.

Authors:  M Larhed; A Hallberg
Journal:  Drug Discov Today       Date:  2001-04-01       Impact factor: 7.851

2.  Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus pectinatus Fisch. et Mey. Var. pectinatus (Lamiaceae).

Authors:  Gülhan Vardar-Unlü; Ferda Candan; Atalay Sökmen; Dimitra Daferera; Moschos Polissiou; Münevver Sökmen; Erol Dönmez; Bektaş Tepe
Journal:  J Agric Food Chem       Date:  2003-01-01       Impact factor: 5.279

3.  Regioselective reaction: synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles.

Authors:  Arun M Isloor; Balakrishna Kalluraya; Prashanth Shetty
Journal:  Eur J Med Chem       Date:  2009-05-05       Impact factor: 6.514

4.  Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Authors:  Hung Yi Kristal Kaan; Venkatasubramanian Ulaganathan; Oliver Rath; Hana Prokopcová; Doris Dallinger; C Oliver Kappe; Frank Kozielski
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

5.  Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.

Authors:  K V Sujith; Jyothi N Rao; Prashanth Shetty; Balakrishna Kalluraya
Journal:  Eur J Med Chem       Date:  2009-04-14       Impact factor: 6.514

6.  2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly.

Authors:  Xuejun Zhu; Guoming Zhao; Xiaoping Zhou; Xiaoqian Xu; Guangqiang Xia; Zhibing Zheng; Lili Wang; Xiaohong Yang; Song Li
Journal:  Bioorg Med Chem Lett       Date:  2009-10-30       Impact factor: 2.823

7.  Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.

Authors:  Clark A Sehon; Gren Z Wang; Andrew Q Viet; Krista B Goodman; Sarah E Dowdell; Patricia A Elkins; Simon F Semus; Christopher Evans; Larry J Jolivette; Robert B Kirkpatrick; Edward Dul; Sanjay S Khandekar; Tracey Yi; Lois L Wright; Gary K Smith; David J Behm; Ross Bentley; Christopher P Doe; Erding Hu; Dennis Lee
Journal:  J Med Chem       Date:  2008-10-09       Impact factor: 7.446

8.  Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones.

Authors:  S Chitra; D Devanathan; K Pandiarajan
Journal:  Eur J Med Chem       Date:  2009-09-16       Impact factor: 6.514

9.  Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Authors:  Annette N Chiang; Juan-Carlos Valderramos; Raghavan Balachandran; Raj J Chovatiya; Brian P Mead; Corinne Schneider; Samantha L Bell; Michael G Klein; Donna M Huryn; Xiaojiang S Chen; Billy W Day; David A Fidock; Peter Wipf; Jeffrey L Brodsky
Journal:  Bioorg Med Chem       Date:  2009-01-20       Impact factor: 3.641

10.  N1-Alkylated 3,4-dihydropyrimidine-2(1H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity.

Authors:  Kamaljit Singh; Divya Arora; Elizabeth Poremsky; Jazmyne Lowery; Robert S Moreland
Journal:  Eur J Med Chem       Date:  2008-10-11       Impact factor: 6.514

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