Literature DB >> 29349521

Recent developments in the synthesis and applications of dihydropyrimidin-2(1H)-ones and thiones.

Behzad Mohammadi1, Farahnaz K Behbahani2.   

Abstract

Dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are important heterocyclic compounds owing to their excellent biological activities and have been widely utilized in pharmaceutical applications. Recently, numerous DHPM derivatives have been prepared. This review covers the synthesis of DHPMs and improved procedures for the preparation of DHPMs from 1995 to 2016.

Entities:  

Keywords:  DHPMs; Dihydropyrimidin-2(1H)-ones; Dihydropyrimidin-2(1H)-ones/thiones; MCRs; Multicomponent reaction; Three-component reaction

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Substances：

Year:  2018        PMID： 29349521     DOI： 10.1007/s11030-017-9806-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  26 in total

1.  Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones.

Authors:  Ahmed Kamal; M Shaheer Malik; Shaik Bajee; Shaik Azeeza; Shaikh Faazil; Sistla Ramakrishna; V G M Naidu; M V P S Vishnuwardhan
Journal:  Eur J Med Chem       Date:  2011-05-05       Impact factor: 6.514

2.  Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies.

Authors:  Kamaljit Singh; Kawaljit Singh; Danielle M Trappanese; Robert S Moreland
Journal:  Eur J Med Chem       Date:  2012-05-26       Impact factor: 6.514

3.  Novel hybrid DHPM-fatty acids: synthesis and activity against glioma cell growth in vitro.

Authors:  Tamara G M Treptow; Fabrício Figueiró; Elisa H F Jandrey; Ana M O Battastini; Christianne G Salbego; Juliana B Hoppe; Priscila S Taborda; Sabrina B Rosa; Luciana A Piovesan; Caroline Da R Montes D'Oca; Dennis Russowsky; Marcelo G Montes D'Oca
Journal:  Eur J Med Chem       Date:  2015-03-28       Impact factor: 6.514

4.  Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds.

Authors:  Vanitha Ramachandran; Karthiga Arumugasamy; Sanjeev Kumar Singh; Naushad Edayadulla; Penugonda Ramesh; Sathish-Kumar Kamaraj
Journal:  J Chem Biol       Date:  2015-07-04

5.  Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists.

Authors:  Harrie J M Gijsen; Didier Berthelot; Michel A J De Cleyn; Ivo Geuens; Bert Brône; Marc Mercken
Journal:  Bioorg Med Chem Lett       Date:  2011-12-22       Impact factor: 2.823

6.  Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.

Authors:  Sarawalee Arunkhamkaew; Anan Athipornchai; Nuttapon Apiratikul; Apichart Suksamrarn; Vachiraporn Ajavakom
Journal:  Bioorg Med Chem Lett       Date:  2013-04-01       Impact factor: 2.823

7.  Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease.

Authors:  Flavio A R Barbosa; Rômulo F S Canto; Sumbal Saba; Jamal Rafique; Antonio L Braga
Journal:  Bioorg Med Chem       Date:  2016-09-13       Impact factor: 3.641

8.  A practical and green approach towards synthesis of dihydropyrimidinones: using heteropoly acids as efficient catalysts.

Authors:  Ezzat Rafiee; Hadi Jafari
Journal:  Bioorg Med Chem Lett       Date:  2006-02-07       Impact factor: 2.823

9.  Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones.

Authors:  S Chitra; D Devanathan; K Pandiarajan
Journal:  Eur J Med Chem       Date:  2009-09-16       Impact factor: 6.514

10.  N1-Alkylated 3,4-dihydropyrimidine-2(1H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity.

Authors:  Kamaljit Singh; Divya Arora; Elizabeth Poremsky; Jazmyne Lowery; Robert S Moreland
Journal:  Eur J Med Chem       Date:  2008-10-11       Impact factor: 6.514
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  2 in total

1.  Visible-Light-Induced Radical Condensation Cyclization to Synthesize 3,4-Dihydropyrimidin-2-(1H)-ones/thiones Using Photoexcited Na2 Eosin Y as a Direct Hydrogen Atom Transfer (HAT) Catalyst.

Authors:  Farzaneh Mohamadpour
Journal:  ACS Omega       Date:  2022-03-03

Review 2.  The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers.

Authors:  Thomas C Chen; Clovis O da Fonseca; Daniel Levin; Axel H Schönthal
Journal:  Pharmaceutics       Date:  2021-12-16       Impact factor: 6.321
  2 in total

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