Literature DB >> 18992814

Engineering natural products using combinatorial biosynthesis and biocatalysis.

Hui Zhou1, Xinkai Xie, Yi Tang.   

Abstract

Many biologically active natural products are produced by the host organisms using dedicated biosynthetic pathways. The programming rules of these pathways may be rationally manipulated through combinatorial biosynthesis to produce natural products that contain structural variations or enhanced pharmacological properties. Furthermore, these pathways contain enzymes that can be harvested as powerful biocatalysts for the synthesis of both new drugs and existing blockbuster therapeutics. This review will highlight recent advances in exploring natural product biosynthetic pathways for new compounds, novel enzymes and useful biocatalysts.

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Year:  2008        PMID： 18992814     DOI： 10.1016/j.copbio.2008.10.012

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  13 in total

1.  Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

Authors:  Effendi Leonard; Parayil Kumaran Ajikumar; Kelly Thayer; Wen-Hai Xiao; Jeffrey D Mo; Bruce Tidor; Gregory Stephanopoulos; Kristala L J Prather
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-19       Impact factor: 11.205

2.  Biosynthesis: is it time to go retro?

Authors:  Brian O Bachmann
Journal:  Nat Chem Biol       Date:  2010-06       Impact factor: 15.040

Review 3.  Protein engineering towards natural product synthesis and diversification.

Authors:  Angelica O Zabala; Ralph A Cacho; Yi Tang
Journal:  J Ind Microbiol Biotechnol       Date:  2011-10-18       Impact factor: 3.346

4.  Directed evolution and structural characterization of a simvastatin synthase.

Authors:  Xue Gao; Xinkai Xie; Inna Pashkov; Michael R Sawaya; Janel Laidman; Wenjun Zhang; Ralph Cacho; Todd O Yeates; Yi Tang
Journal:  Chem Biol       Date:  2009-10-30

Review 5.  Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

Authors:  Keshav K Nepal; Guojun Wang
Journal:  Biotechnol Adv       Date:  2018-10-09       Impact factor: 14.227

6.  The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.

Authors:  Nicholas Noinaj; Mary A Bosserman; M Alexandra Schickli; Grzegorz Piszczek; Madan K Kharel; Pallab Pahari; Susan K Buchanan; Jürgen Rohr
Journal:  J Biol Chem       Date:  2011-05-10       Impact factor: 5.157

7.  Directed evolution as a powerful synthetic biology tool.

Authors:  Ryan E Cobb; Ning Sun; Huimin Zhao
Journal:  Methods       Date:  2012-03-23       Impact factor: 3.608

Review 8.  Resistance to and synthesis of the antibiotic mupirocin.

Authors:  Christopher M Thomas; Joanne Hothersall; Christine L Willis; Thomas J Simpson
Journal:  Nat Rev Microbiol       Date:  2010-03-01       Impact factor: 60.633

9.  Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

Authors:  Martina Werneburg; Benjamin Busch; Jing He; Martin E A Richter; Longkuan Xiang; Bradley S Moore; Martin Roth; Hans-Martin Dahse; Christian Hertweck
Journal:  J Am Chem Soc       Date:  2010-08-04       Impact factor: 15.419

10.  Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis.

Authors:  Sibongile Mafu; Meirong Jia; Jiachen Zi; Dana Morrone; Yisheng Wu; Meimei Xu; Matthew L Hillwig; Reuben J Peters
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205
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