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Literature DB >> 20190824

Resistance to and synthesis of the antibiotic mupirocin.

Christopher M Thomas¹, Joanne Hothersall, Christine L Willis, Thomas J Simpson.

Abstract

Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20190824 DOI： 10.1038/nrmicro2278

Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633

58 in total

1. Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus.

Authors: Martin Antonio; Neil McFerran; Mark J Pallen
Journal: Antimicrob Agents Chemother Date: 2002-02 Impact factor: 5.191

2. The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity.

Authors: N J Broom; R Cassels; H Y Cheng; J S Elder; P C Hannan; N Masson; P J O'Hanlon; A Pope; J M Wilson
Journal: J Med Chem Date: 1996-08-30 Impact factor: 7.446

3. Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.

Authors: Julian Gregston Hurdle; Alexander John O'Neill; Eileen Ingham; Colin Fishwick; Ian Chopra
Journal: Antimicrob Agents Chemother Date: 2004-11 Impact factor: 5.191

4. Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.

Authors: Ayesha S Rahman; Joanne Hothersall; John Crosby; Thomas J Simpson; Christopher M Thomas
Journal: J Biol Chem Date: 2004-12-06 Impact factor: 5.157

Review 5. Isoprenoid-like alkylations in polyketide biosynthesis.

Authors: Christopher T Calderone
Journal: Nat Prod Rep Date: 2008-06-18 Impact factor: 13.423

6. Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

Authors: A Kassem El-Sayed; Joanne Hothersall; Sian M Cooper; Elton Stephens; Thomas J Simpson; Christopher M Thomas
Journal: Chem Biol Date: 2003-05

7. Mupirocin resistance screening of methicillin-resistant Staphylococcus aureus isolates at Madigan Army Medical Center.

Authors: Dana Perkins; Jacob S Hogue; Mary Fairchok; LoRanée Braun; Helen B Viscount
Journal: Mil Med Date: 2008-06 Impact factor: 1.437

8. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use.

Authors: R Sutherland; R J Boon; K E Griffin; P J Masters; B Slocombe; A R White
Journal: Antimicrob Agents Chemother Date: 1985-04 Impact factor: 5.191

Review 9. Mupirocin resistance.

Authors: Jean B Patel; Rachel J Gorwitz; John A Jernigan
Journal: Clin Infect Dis Date: 2009-09-15 Impact factor: 9.079

Review 9. Emergence and evolution.

Authors: Tammy J Bullwinkle; Michael Ibba
Journal: Top Curr Chem Date: 2014

10. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.

Authors: I G Azcárate; P Marín-García; N Camacho; S Pérez-Benavente; A Puyet; A Diez; L Ribas de Pouplana; J M Bautista
Journal: Br J Pharmacol Date: 2013-06 Impact factor: 8.739

Resistance to and synthesis of the antibiotic mupirocin.

1. Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus.

2. The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity.

3. Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.

4. Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.

Review 5. Isoprenoid-like alkylations in polyketide biosynthesis.

6. Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

7. Mupirocin resistance screening of methicillin-resistant Staphylococcus aureus isolates at Madigan Army Medical Center.

8. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use.

Review 9. Mupirocin resistance.

10. Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium.

Review 1. Prevention of Recurrent Staphylococcal Skin Infections.

2. Enzymatic basis of "hybridity" in thiomarinol biosynthesis.

3. Insights into physiological and genetic mupirocin susceptibility in bifidobacteria.

Review 4. Biased gene transfer in microbial evolution.

5. Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli.

6. Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation.

Review 7. Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.

Review 8. Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Review 9. Emergence and evolution.

10. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.