| Literature DB >> 1899105 |
S E Alters1, J A Shizuru, J Ackerman, D Grossman, K B Seydel, C G Fathman.
Abstract
Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.Entities:
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Year: 1991 PMID： 1899105 PMCID： PMC2118801 DOI： 10.1084/jem.173.2.491
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307