Literature DB >> 2647894

Induction of classical transplantation tolerance in the adult.

S X Qin1, S Cobbold, R Benjamin, H Waldmann.   

Abstract

Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.

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Year:  1989        PMID： 2647894      PMCID： PMC2189271          DOI： 10.1084/jem.169.3.779

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  28 in total

1.  Actively acquired tolerance of foreign cells.

Authors:  R E BILLINGHAM; L BRENT; P B MEDAWAR
Journal:  Nature       Date:  1953-10-03       Impact factor: 49.962

2.  Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

Authors:  N L Carteron; D Wofsy; W E Seaman
Journal:  J Immunol       Date:  1988-02-01       Impact factor: 5.422

3.  Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.

Authors:  B J Fowlkes; R H Schwartz; D M Pardoll
Journal:  Nature       Date:  1988-08-18       Impact factor: 49.962

4.  Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

Authors:  C C Goodnow; J Crosbie; S Adelstein; T B Lavoie; S J Smith-Gill; R A Brink; H Pritchard-Briscoe; J S Wotherspoon; R H Loblay; K Raphael
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

5.  Mechanisms of marrow graft rejection in murine model systems.

Authors:  G Dennert; C Knobloch; B Yankelevich
Journal:  Transplant Proc       Date:  1987-12       Impact factor: 1.066

6.  Drug-induced tolerance to allografts in mice. IX. Establishment of complete chimerism by allogeneic spleen cell transplantation from donors made tolerant to H-2-identical recipients.

Authors:  H Mayumi; K Himeno; K Tanaka; N Tokuda; J L Fan; K Nomoto
Journal:  Transplantation       Date:  1986-10       Impact factor: 4.939

7.  T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation.

Authors:  G Hale; S Cobbold; H Waldmann
Journal:  Transplantation       Date:  1988-04       Impact factor: 4.939

8.  Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination.

Authors:  R J Benjamin; S X Qin; M P Wise; S P Cobbold; H Waldmann
Journal:  Eur J Immunol       Date:  1988-07       Impact factor: 5.532

9.  Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

Authors:  H R MacDonald; T Pedrazzini; R Schneider; J A Louis; R M Zinkernagel; H Hengartner
Journal:  J Exp Med       Date:  1988-06-01       Impact factor: 14.307

10.  Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

Authors:  M K Jenkins; R H Schwartz
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307
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  61 in total

Review 1.  Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?

Authors:  K Honey; S P Cobbold; H Waldmann
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

2.  Importance of intrathymic mixed chimerism for the maintenance of skin allograft tolerance across fully allogeneic antigens in mice.

Authors:  M Eto; Y Y Kong; J Uozumi; S Naito; K Nomoto
Journal:  Immunology       Date:  1999-03       Impact factor: 7.397

Review 3.  Tolerance: an overview and perspectives.

Authors:  Herman Waldmann
Journal:  Nat Rev Nephrol       Date:  2010-08-17       Impact factor: 28.314

Review 4.  Perspectives in transplantation immunology 1991.

Authors:  D Kabelitz; M L da Silva Lobo; K Pechhold
Journal:  Klin Wochenschr       Date:  1991-09-03

Review 5.  Control of self-reactivity in the intestine.

Authors:  T A Barrett; S M Hedrick; A L Dent; M L Delvy; D M Kennedy; L A Matis; J A Bluestone
Journal:  Immunol Res       Date:  1991       Impact factor: 2.829

6.  Reshaping a therapeutic CD4 antibody.

Authors:  S D Gorman; M R Clark; E G Routledge; S P Cobbold; H Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

7.  Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.

Authors:  K Wieties; R E Hammer; S Jones-Youngblood; J Forman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

8.  CD8 blockade promotes the expansion of antigen-specific CD4+ FOXP3+ regulatory T cells in vivo.

Authors:  Z Wang; J D Davies
Journal:  Int Immunopharmacol       Date:  2006-11-28       Impact factor: 4.932

9.  Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies.

Authors:  G G Oliveira; P R Hutchings; I M Roitt; P M Lydyard
Journal:  Clin Exp Immunol       Date:  1994-05       Impact factor: 4.330

10.  A comparative study of T-cell receptor V beta usage in non-obese diabetic (NOD) and I-E transgenic NOD mice.

Authors:  N M Parish; H Acha-Orbea; E Simpson; S X Qin; T Lund; A Cooke
Journal:  Immunology       Date:  1993-04       Impact factor: 7.397
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