Literature DB >> 18977499

Making artemisinin.

Patrick S Covello1.   

Abstract

The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.

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Year:  2008        PMID: 18977499     DOI: 10.1016/j.phytochem.2008.10.001

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  39 in total

1.  Generation of the potent anti-malarial drug artemisinin in tobacco.

Authors:  Moran Farhi; Elena Marhevka; Julius Ben-Ari; Anna Algamas-Dimantov; Zhuobin Liang; Vardit Zeevi; Orit Edelbaum; Ben Spitzer-Rimon; Hagai Abeliovich; Betty Schwartz; Tzvi Tzfira; Alexander Vainstein
Journal:  Nat Biotechnol       Date:  2011-12-08       Impact factor: 54.908

2.  Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua.

Authors:  Patrick R Arsenault; Daniel Vail; Kristin K Wobbe; Karen Erickson; Pamela J Weathers
Journal:  Plant Physiol       Date:  2010-08-19       Impact factor: 8.340

Review 3.  The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

Authors:  Geoffrey D Brown
Journal:  Molecules       Date:  2010-10-28       Impact factor: 4.411

4.  Translational synthetic biology.

Authors:  Mamta Singh; Anuradha Vaidya
Journal:  Syst Synth Biol       Date:  2015-08-18

Review 5.  Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules.

Authors:  Sarah A Wilson; Susan C Roberts
Journal:  Plant Biotechnol J       Date:  2011-11-08       Impact factor: 9.803

6.  Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

Authors:  Khanhvan T Nguyen; Patrick R Arsenault; Pamela J Weathers
Journal:  In Vitro Cell Dev Biol Plant       Date:  2011-06       Impact factor: 2.252

7.  Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.

Authors:  Pamela J Weathers; Patrick R Arsenault; Patrick S Covello; Anthony McMickle; Keat H Teoh; Darwin W Reed
Journal:  Phytochem Rev       Date:  2011-06       Impact factor: 5.374

Review 8.  21st century natural product research and drug development and traditional medicines.

Authors:  Linh T Ngo; Joseph I Okogun; William R Folk
Journal:  Nat Prod Rep       Date:  2013-04       Impact factor: 13.423

9.  Survey of artemisinin production by diverse Artemisia species in northern Pakistan.

Authors:  Abdul Mannan; Ibrar Ahmed; Waheed Arshad; Muhammad F Asim; Rizwana A Qureshi; Izhar Hussain; Bushra Mirza
Journal:  Malar J       Date:  2010-11-04       Impact factor: 2.979

10.  Autofluorescence as a Signal to Sort Developing Glandular Trichomes by Flow Cytometry.

Authors:  Nick Bergau; Alexander Navarette Santos; Anja Henning; Gerd U Balcke; Alain Tissier
Journal:  Front Plant Sci       Date:  2016-06-28       Impact factor: 5.753

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