Literature DB >> 21666770

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

Khanhvan T Nguyen1, Patrick R Arsenault, Pamela J Weathers.   

Abstract

Artemisinin is a highly effective sesquiterpene lactone therapeutic produced in the plant, Artemisia annua. Despite its efficacy against malaria and many other infectious diseases and neoplasms, the drug is in short supply mainly because the plant produces low levels of the compound. This review updates the current understanding of artemisinin biosynthesis with a special focus on the emerging knowledge of how biosynthesis of the compound is regulated in planta.

Entities:  

Year:  2011        PMID： 21666770      PMCID： PMC3110715          DOI： 10.1007/s11627-011-9343-x

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol Plant        ISSN： 1054-5476            Impact factor:   2.252


  47 in total

1.  Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes.

Authors:  T E Wallaart; N Pras; A C Beekman; W J Quax
Journal:  Planta Med       Date:  2000-02       Impact factor: 3.352

2.  Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry.

Authors:  Chenfei Ma; Huahong Wang; Xin Lu; Guowang Xu; Benye Liu
Journal:  J Chromatogr A       Date:  2007-09-16       Impact factor: 4.759

3.  The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua.

Authors:  Anna-Margareta Rydén; Carolien Ruyter-Spira; Wim J Quax; Hiroyuki Osada; Toshiya Muranaka; Oliver Kayser; Harro Bouwmeester
Journal:  Planta Med       Date:  2010-05-19       Impact factor: 3.352

4.  Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.

Authors:  Keat H Teoh; Devin R Polichuk; Darwin W Reed; Goska Nowak; Patrick S Covello
Journal:  FEBS Lett       Date:  2006-01-30       Impact factor: 4.124

5.  Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L.

Authors:  P Mercke; M Bengtsson; H J Bouwmeester; M A Posthumus; P E Brodelius
Journal:  Arch Biochem Biophys       Date:  2000-09-15       Impact factor: 4.013

6.  Effects of arbuscular mycorrhiza and phosphorus application on artemisinin concentration in Artemisia annua L.

Authors:  Rupam Kapoor; Vidhi Chaudhary; A K Bhatnagar
Journal:  Mycorrhiza       Date:  2007-06-20       Impact factor: 3.387

7.  DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures.

Authors:  Abdul Mannan; Chunzhao Liu; Patrick R Arsenault; Melissa J Towler; Dan R Vail; Argelia Lorence; Pamela J Weathers
Journal:  Plant Cell Rep       Date:  2009-12-20       Impact factor: 4.570

8.  Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana.

Authors:  Soon-Hee Kim; Yung-Jin Chang; Soo-Un Kim
Journal:  Planta Med       Date:  2008-01-17       Impact factor: 3.352

Review 9.  Systemic acquired resistance.

Authors:  W E Durrant; X Dong
Journal:  Annu Rev Phytopathol       Date:  2004       Impact factor: 13.078

10.  Isolation and identification of novel genes involved in artemisinin production from flowers of Artemisia annua using suppression subtractive hybridization and metabolite analysis.

Authors:  Shuoqian Liu; Na Tian; Juan Li; Jianan Huang; Zhonghua Liu
Journal:  Planta Med       Date:  2009-06-23       Impact factor: 3.352
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  15 in total

Review 1.  Transgenic approach to increase artemisinin content in Artemisia annua L.

Authors:  Kexuan Tang; Qian Shen; Tingxiang Yan; Xueqing Fu
Journal:  Plant Cell Rep       Date:  2014-01-12       Impact factor: 4.570

Review 2.  21st century natural product research and drug development and traditional medicines.

Authors:  Linh T Ngo; Joseph I Okogun; William R Folk
Journal:  Nat Prod Rep       Date:  2013-04       Impact factor: 13.423

3.  Artemisinin production and precursor ratio in full grown Artemisia annua L. plants subjected to external stress.

Authors:  Anders Kjær; Francel Verstappen; Harro Bouwmeester; Elise Ivarsen; Xavier Fretté; Lars P Christensen; Kai Grevsen; Martin Jensen
Journal:  Planta       Date:  2012-11-24       Impact factor: 4.116

4.  Artemisinin production by plant hairy root cultures in gas- and liquid-phase bioreactors.

Authors:  Nivedita Patra; Ashok K Srivastava
Journal:  Plant Cell Rep       Date:  2015-10-06       Impact factor: 4.570

5.  The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

Authors:  Khanhvan T Nguyen; Melissa J Towler; Pamela J Weathers
Journal:  Plant Cell Rep       Date:  2012-10-20       Impact factor: 4.570

6.  Artemisia annua L. and photoresponse: from artemisinin accumulation, volatile profile and anatomical modifications to gene expression.

Authors:  Ellen M Lopes; Fábia Guimarães-Dias; Thália do S S Gama; Arthur L Macedo; Alessandra L Valverde; Marcela C de Moraes; Ana Cristina A de Aguiar-Dias; Humberto R Bizzo; Marcio Alves-Ferreira; Eliana S Tavares; Andrea F Macedo
Journal:  Plant Cell Rep       Date:  2019-10-01       Impact factor: 4.570

7.  Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence.

Authors:  Sibo Wang; Melissa J Towler; Pamela J Weathers
Journal:  Planta       Date:  2016-06-23       Impact factor: 4.116

Review 8.  Glandular trichomes: new focus on horticultural crops.

Authors:  Zhongxuan Feng; Ezra S Bartholomew; Ziyu Liu; Yuanyuan Cui; Yuming Dong; Sen Li; Haoying Wu; Huazhong Ren; Xingwang Liu
Journal:  Hortic Res       Date:  2021-07-01       Impact factor: 6.793

9.  Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin.

Authors:  Anders Kjær; Kai Grevsen; Martin Jensen
Journal:  AoB Plants       Date:  2012-06-21       Impact factor: 3.276

10.  Antimicrobial activity of artemisinin and precursor derived from in vitro plantlets of Artemisia annua L.

Authors:  Suganthi Appalasamy; Kiah Yann Lo; Song Jin Ch'ng; Ku Nornadia; Ahmad Sofiman Othman; Lai-Keng Chan
Journal:  Biomed Res Int       Date:  2014-01-19       Impact factor: 3.411
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