Literature DB >> 28392851

Translational synthetic biology.

Mamta Singh1, Anuradha Vaidya1.   

Abstract

Synthetic biology is a recent scientific approach towards engineering biological systems from both pre-existing and novel parts. The aim is to introduce computational aided design approach in biology leading to rapid delivery of useful applications. Though the term reprogramming has been frequently used in the synthetic biology community, currently the technological sophistication only allows for a probabilistic approach instead of a precise engineering approach. Recently, several human health applications have emerged that suggest increased usage of synthetic biology approach in developing novel drugs. This mini review discusses recent translational developments in the field and tries to identify some of the upcoming future developments.

Entities:  

Keywords:  Cancer; Malaria; Neurodegenerative; Synthetic biology; Translational; Tuberculosis

Year:  2015        PMID: 28392851      PMCID: PMC5383794          DOI: 10.1007/s11693-015-9181-y

Source DB:  PubMed          Journal:  Syst Synth Biol        ISSN: 1872-5325


  25 in total

1.  Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Authors:  Frank Soldner; Josée Laganière; Albert W Cheng; Dirk Hockemeyer; Qing Gao; Raaji Alagappan; Vikram Khurana; Lawrence I Golbe; Richard H Myers; Susan Lindquist; Lei Zhang; Dmitry Guschin; Lauren K Fong; B Joseph Vu; Xiangdong Meng; Fyodor D Urnov; Edward J Rebar; Philip D Gregory; H Steve Zhang; Rudolf Jaenisch
Journal:  Cell       Date:  2011-07-14       Impact factor: 41.582

2.  In silico study of peptide inhibitors against BACE 1.

Authors:  Navya Raj; Agnes Helen; N Manoj; G Harish; Vipin Thomas; Shailja Singh; Seema Sehrawat; Shaguna Seth; Achuthsankar S Nair; Abhinav Grover; Pawan K Dhar
Journal:  Syst Synth Biol       Date:  2015-03-19

Review 3.  Synthetic biology in cell-based cancer immunotherapy.

Authors:  Deboki Chakravarti; Wilson W Wong
Journal:  Trends Biotechnol       Date:  2015-06-16       Impact factor: 19.536

4.  Activation of the pro-drug ethionamide is regulated in mycobacteria.

Authors:  A R Baulard; J C Betts; J Engohang-Ndong; S Quan; R A McAdam; P J Brennan; C Locht; G S Besra
Journal:  J Biol Chem       Date:  2000-09-08       Impact factor: 5.157

5.  EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.

Authors:  Jean Engohang-Ndong; David Baillat; Marc Aumercier; Flore Bellefontaine; Gurdyal S Besra; Camille Locht; Alain R Baulard
Journal:  Mol Microbiol       Date:  2004-01       Impact factor: 3.501

Review 6.  Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs.

Authors:  Victoria Hale; Jay D Keasling; Neil Renninger; Thierry T Diagana
Journal:  Am J Trop Med Hyg       Date:  2007-12       Impact factor: 2.345

7.  Alzheimer disease in the US population: prevalence estimates using the 2000 census.

Authors:  Liesi E Hebert; Paul A Scherr; Julia L Bienias; David A Bennett; Denis A Evans
Journal:  Arch Neurol       Date:  2003-08

8.  Synthetic Long Peptide Influenza Vaccine Containing Conserved T and B Cell Epitopes Reduces Viral Load in Lungs of Mice and Ferrets.

Authors:  S K Rosendahl Huber; M G M Camps; R H J Jacobi; J Mouthaan; H van Dijken; J van Beek; F Ossendorp; J de Jonge
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

9.  Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.

Authors:  Helen Fong; Chengzhong Wang; Johanna Knoferle; David Walker; Maureen E Balestra; Leslie M Tong; Laura Leung; Karen L Ring; William W Seeley; Anna Karydas; Mihir A Kshirsagar; Adam L Boxer; Kenneth S Kosik; Bruce L Miller; Yadong Huang
Journal:  Stem Cell Reports       Date:  2013-08-29       Impact factor: 7.765

Review 10.  Synthetic biology.

Authors:  Steven A Benner; A Michael Sismour
Journal:  Nat Rev Genet       Date:  2005-07       Impact factor: 53.242

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  1 in total

1.  Dynamics of problem setting and framing in citizen discussions on synthetic biology.

Authors:  Afke Wieke Betten; Jacqueline E W Broerse; Frank Kupper
Journal:  Public Underst Sci       Date:  2017-06-09
  1 in total

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