Literature DB >> 18949600

PharmGKB: understanding the effects of individual genetic variants.

Katrin Sangkuhl1, Dorit S Berlin, Russ B Altman, Teri E Klein.   

Abstract

The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB: http://www.pharmgkb.org) is devoted to disseminating primary data and knowledge in pharmacogenetics and pharmacogenomics. We are annotating the genes that are most important for drug response and present this information in the form of Very Important Pharmacogene (VIP) summaries, pathway diagrams, and curated literature. The PharmGKB currently contains information on over 500 drugs, 500 diseases, and 700 genes with genotyped variants. New features focus on capturing the phenotypic consequences of individual genetic variants. These features link variant genotypes to phenotypes, increase the breadth of pharmacogenomics literature curated, and visualize single-nucleotide polymorphisms on a gene's three-dimensional protein structure.

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Year:  2008        PMID： 18949600      PMCID： PMC2677552          DOI： 10.1080/03602530802413338

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN： 0360-2532            Impact factor:   4.518


  17 in total

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6.  Genetic epidemiology of pharmacogenetic variants in South East Asian Malays using whole-genome sequences.

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7.  The Clinical Genome and Ancestry Report: An interactive web application for prioritizing clinically implicated variants from genome sequencing data with ancestry composition.

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10.  T3DB: a comprehensively annotated database of common toxins and their targets.

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