Gee Su Yang1, Natalie M Barnes2, Debra E Lyon2, Susan G Dorsey3. 1. University of Florida College of Nursing, Gainesville, FL. Electronic address: gyang1@ufl.edu. 2. University of Florida College of Nursing, Gainesville, FL. 3. University of Maryland School of Nursing, Department of Pain and Translational Symptom Science, Baltimore, MD. Electronic address: sdorsey@umaryland.edu.
Abstract
OBJECTIVE: To review the current knowledge on the association of genetic variants with cancer pain. DATA SOURCES: Data-based publications and review articles retrieved from PubMed, CINAHL, and Web of Science, as well as an additional search in Google Scholar. CONCLUSION: Genetic variability can influence differential pain perception and response to opioids in cancer patients, which will have implications in the optimal personalized treatment of cancer pain. More studies are warranted to replicate findings. IMPLICATIONS FOR NURSING PRACTICE: Nurses are poised to educate patients on biomarker testing and interpretation and to use precision pain management strategies based on this information.
OBJECTIVE: To review the current knowledge on the association of genetic variants with cancer pain. DATA SOURCES: Data-based publications and review articles retrieved from PubMed, CINAHL, and Web of Science, as well as an additional search in Google Scholar. CONCLUSION: Genetic variability can influence differential pain perception and response to opioids in cancerpatients, which will have implications in the optimal personalized treatment of cancer pain. More studies are warranted to replicate findings. IMPLICATIONS FOR NURSING PRACTICE: Nurses are poised to educate patients on biomarker testing and interpretation and to use precision pain management strategies based on this information.
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