Literature DB >> 18948193

The multienzyme architecture of eukaryotic fatty acid synthases.

Marc Leibundgut1, Timm Maier, Simon Jenni, Nenad Ban.   

Abstract

Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic steps essential for fatty acid biosynthesis. Recent crystallographic studies provide new insights into the architecture of the two distinct eukaryotic FAS systems, the 2.6 MDa heterododecameric fungal and the 540 kDa dimeric animal FAS. In this review, we compare the fundamentally different organization of these two megasynthases and discuss the structural principles of enzyme integration and substrate shuttling in FAS multienzymes.

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Year:  2008        PMID： 18948193     DOI： 10.1016/j.sbi.2008.09.008

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  49 in total

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