Literature DB >> 1892400

Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay.

H Babich1, E Borenfreund.   

Abstract

The neutral red (NR) cell viability assay was used with various cell types of human origin to quantitate the potency of T-2 mycotoxin and its metabolites. The human melanoma SK-Mel/27 cell line was the most sensitive, with a midpoint cytotoxicity value of 2.8 ng of T-2 per ml. With the human hepatoma cell line, HepG2, the sequence of potency for a series of mycotoxins was T-2 greater than HT-2 greater than T-2 triol greater than T-2 tetraol.

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Year:  1991        PMID： 1892400      PMCID： PMC183530          DOI： 10.1128/aem.57.7.2101-2103.1991

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  22 in total

1.  In vivo effects of T-2 mycotoxin on synthesis of proteins and DNA in rat tissues.

Authors:  W L Thompson; R W Wannemacher
Journal:  Toxicol Appl Pharmacol       Date:  1990-09-15       Impact factor: 4.219

2.  Use of cell cultures for predicting the biological effects of mycotoxins.

Authors:  S Robbana-Barnat; C Lafarge-Frayssinet; C Frayssinet
Journal:  Cell Biol Toxicol       Date:  1989-06       Impact factor: 6.691

3.  Toxicological approaches to the metabolites of Fusaria. I. Screening of toxic strains.

Authors:  Y Ueno; Y Ishikawa; M Nakajima; K Sakai; K Ishii
Journal:  Jpn J Exp Med       Date:  1971-08

4.  Detection and quantitation of T-2 mycotoxin with a simplified protein synthesis inhibition assay.

Authors:  W L Thompson; R W Wannemacher
Journal:  Appl Environ Microbiol       Date:  1984-12       Impact factor: 4.792

5.  Cytotoxic effect of T-2 mycotoxin on cells in culture as determined by a rapid colorimetric bioassay.

Authors:  P S Holt; S Buckley; J O Norman; J R DeLoach
Journal:  Toxicon       Date:  1988       Impact factor: 3.033

6.  Induction of chromosome aberrations by fusarium T-2 toxin in cultured human peripheral blood lymphocytes and Chinese hamster fibroblasts.

Authors:  C C Hsia; Y Gao; J L Wu; B L Tzian
Journal:  J Cell Physiol Suppl       Date:  1986

7.  Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.

Authors:  F Denizot; R Lang
Journal:  J Immunol Methods       Date:  1986-05-22       Impact factor: 2.303

8.  Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.

Authors:  H Babich; M K Sardana; E Borenfreund
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691
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  30 in total

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5.  Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.

Authors:  Karumanchi V Rao; Marwa S Donia; Jiangnan Peng; Esther Garcia-Palomero; Diana Alonso; Ana Martinez; Miguel Medina; Scott G Franzblau; Babu L Tekwani; Shabana I Khan; Subagus Wahyuono; Kristine L Willett; Mark T Hamann
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6.  In vivo characterization of fusion protein comprising of A1 subunit of Shiga toxin and human GM-CSF: Assessment of its immunogenicity and toxicity.

Authors:  Mana Oloomi; Saeid Bouzari; Elaheh Shariati
Journal:  Iran Biomed J       Date:  2010-10

7.  Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.

Authors:  D Pubill; E Verdaguer; A M Canudas; F X Sureda; E Escubedo; J Camarasa; M Pallàs; A Camins
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

8.  Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

Authors:  Diego G Ghiano; Agustina de la Iglesia; Nina Liu; Peter J Tonge; Héctor R Morbidoni; Guillermo R Labadie
Journal:  Eur J Med Chem       Date:  2016-09-28       Impact factor: 6.514

9.  Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.

Authors:  Julia Fernández de Luco; Alejandro I Recio-Balsells; Diego G Ghiano; Ana Bortolotti; Juán Manuel Belardinelli; Nina Liu; Pascal Hoffmann; Christian Lherbet; Peter J Tonge; Babu Tekwani; Héctor R Morbidoni; Guillermo R Labadie
Journal:  RSC Med Chem       Date:  2020-11-05

10.  Internalization of Proteus mirabilis by human renal epithelial cells.

Authors:  G R Chippendale; J W Warren; A L Trifillis; H L Mobley
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441
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