Literature DB >> 21633789

Targeting tuberculosis through a small focused library of 1,2,3-triazoles.

Guillermo R Labadie1, Agustina de la Iglesia, Héctor R Morbidoni.   

Abstract

Looking for new active molecules against Mycobacterium tuberculosis, a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis. Two of them showed MIC at lower μg/mL concentration for M. avium and even below that for M. tuberculosis, being more potent that control drugs.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21633789     DOI： 10.1007/s11030-011-9319-0

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  42 in total

1.  Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides.

Authors:  Rushia A Turner; Allen G Oliver; R Scott Lokey
Journal:  Org Lett       Date:  2007-10-23       Impact factor: 6.005

2.  The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase.

Authors:  Qingjun Ma; Xin Zhao; Ali Nasser Eddine; Arie Geerlof; Xinping Li; John E Cronan; Stefan H E Kaufmann; Matthias Wilmanns
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-30       Impact factor: 11.205

3.  The potential of azole antifungals against latent/persistent tuberculosis.

Authors:  Zahoor Ahmad; Sadhna Sharma; Gopal K Khuller
Journal:  FEMS Microbiol Lett       Date:  2006-05       Impact factor: 2.742

4.  Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives.

Authors:  Kadir Dabak; Ozkan Sezer; Ahmet Akar; Olcay Anaç
Journal:  Eur J Med Chem       Date:  2003-02       Impact factor: 6.514

5.  Oxazolomycins: natural product lead structures for novel antibacterials by click fragment conjugation.

Authors:  Claire L Bagwell; Mark G Moloney; Muhammad Yaqoob
Journal:  Bioorg Med Chem Lett       Date:  2010-02-20       Impact factor: 2.823

Review 6.  Antituberculosis drugs: ten years of research.

Authors:  Yves L Janin
Journal:  Bioorg Med Chem       Date:  2007-01-19       Impact factor: 3.641

7.  Synthesis of spiroacetal-triazoles as privileged natural product-like scaffolds using "click chemistry".

Authors:  Ka Wai Choi; Margaret A Brimble
Journal:  Org Biomol Chem       Date:  2008-08-05       Impact factor: 3.876

8.  Clubbed [1,2,3] triazoles by fluorine benzimidazole: a novel approach to H37Rv inhibitors as a potential treatment for tuberculosis.

Authors:  Charansingh Gill; Ganesh Jadhav; Mohammad Shaikh; Rajesh Kale; Anant Ghawalkar; Deepak Nagargoje; Mahendra Shiradkar
Journal:  Bioorg Med Chem Lett       Date:  2008-10-02       Impact factor: 2.823

9.  Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents.

Authors:  Mahendra Ramesh Shiradkar; Kiran Kumar Murahari; Hanimi Reddy Gangadasu; Tatikonda Suresh; Chakravarthy Akula Kalyan; Dolly Panchal; Ranjit Kaur; Prashant Burange; Jyoti Ghogare; Vinod Mokale; Mayuresh Raut
Journal:  Bioorg Med Chem       Date:  2007-04-06       Impact factor: 3.641

10.  SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents.

Authors:  Ganesh Rajaram Jadhav; Mohammad Usman Shaikh; Rajesh Prabhakar Kale; Mahendra Ramesh Shiradkar; Charansingh Harnamsingh Gill
Journal:  Eur J Med Chem       Date:  2008-12-16       Impact factor: 6.514
View more
  5 in total

1.  Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

Authors:  Diego G Ghiano; Agustina de la Iglesia; Nina Liu; Peter J Tonge; Héctor R Morbidoni; Guillermo R Labadie
Journal:  Eur J Med Chem       Date:  2016-09-28       Impact factor: 6.514

2.  Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.

Authors:  Julia Fernández de Luco; Alejandro I Recio-Balsells; Diego G Ghiano; Ana Bortolotti; Juán Manuel Belardinelli; Nina Liu; Pascal Hoffmann; Christian Lherbet; Peter J Tonge; Babu Tekwani; Héctor R Morbidoni; Guillermo R Labadie
Journal:  RSC Med Chem       Date:  2020-11-05

Review 3.  Triazole, imidazole, and thiazole-based compounds as potential agents against coronavirus.

Authors:  Insa Seck; Filomain Nguemo
Journal:  Results Chem       Date:  2021-04-22

4.  Design, Synthesis, in vitro and in silico Characterization of 2-Quinolone-L-alaninate-1,2,3-triazoles as Antimicrobial Agents.

Authors:  Oussama Moussaoui; Rajendra Bhadane; Riham Sghyar; Janez Ilaš; El Mestafa El Hadrami; Said Chakroune; Outi M H Salo-Ahen
Journal:  ChemMedChem       Date:  2022-01-27       Impact factor: 3.540

5.  Targeting L-Proline Uptake as New Strategy for Anti-chagas Drug Development.

Authors:  Lucía Fargnoli; Esteban A Panozzo-Zénere; Lucas Pagura; María Julia Barisón; Julia A Cricco; Ariel M Silber; Guillermo R Labadie
Journal:  Front Chem       Date:  2020-08-25       Impact factor: 5.221
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.