Literature DB >> 18854148

DNA repair by the MRN complex: break it to make it.

Roland Kanaar1, Claire Wyman.   

Abstract

Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

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Year:  2008        PMID： 18854148     DOI： 10.1016/j.cell.2008.09.027

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  14 in total

1.  Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.

Authors:  Josef Loidl; Kazufumi Mochizuki
Journal:  Mol Biol Cell       Date:  2009-03-18       Impact factor: 4.138

Review 2.  Activation and regulation of DNA-driven immune responses.

Authors:  Søren R Paludan
Journal:  Microbiol Mol Biol Rev       Date:  2015-06       Impact factor: 11.056

Review 3.  Sharpening the ends for repair: mechanisms and regulation of DNA resection.

Authors:  Sharad C Paudyal; Zhongsheng You
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2016-05-12       Impact factor: 3.848

Review 4.  The interplay between DNA repair and autophagy in cancer therapy.

Authors:  Dan Zhang; Bo Tang; Xia Xie; Yu-Feng Xiao; Shi-Ming Yang; Jian-Wei Zhang
Journal:  Cancer Biol Ther       Date:  2015-05-18       Impact factor: 4.742

5.  Mre11-Rad50 complex crystals suggest molecular calisthenics.

Authors:  Claire Wyman; Joyce Lebbink; Roland Kanaar
Journal:  DNA Repair (Amst)       Date:  2011-09-04

6.  TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei.

Authors:  Hee-Sook Kim; George A M Cross
Journal:  PLoS Pathog       Date:  2010-07-08       Impact factor: 6.823

7.  Inventory and phylogenetic analysis of meiotic genes in monogonont rotifers.

Authors:  Sara J Hanson; Andrew M Schurko; Bette Hecox-Lea; David B Mark Welch; Claus-Peter Stelzer; John M Logsdon
Journal:  J Hered       Date:  2013-03-13       Impact factor: 2.645

Review 8.  The DNA damage response: making it safe to play with knives.

Authors:  Alberto Ciccia; Stephen J Elledge
Journal:  Mol Cell       Date:  2010-10-22       Impact factor: 17.970

Review 9.  SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end-joining.

Authors:  Meghana Manjunath; Bibha Choudhary; Sathees C Raghavan
Journal:  Cancer Rep (Hoboken)       Date:  2021-01-26

10.  The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.

Authors:  Joon Lee; William G Dunphy
Journal:  Mol Biol Cell       Date:  2013-03-06       Impact factor: 4.138
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