Literature DB >> 21893433

Mre11-Rad50 complex crystals suggest molecular calisthenics.

Claire Wyman1, Joyce Lebbink, Roland Kanaar.   

Abstract

Recently published crystal structures of different Mre11 and Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important functional consequences.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21893433      PMCID： PMC3185151          DOI： 10.1016/j.dnarep.2011.07.008

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  33 in total

Review 1.  Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.

Authors:  Gareth J Williams; Susan P Lees-Miller; John A Tainer
Journal:  DNA Repair (Amst)       Date:  2010-10-28

2.  DNA repair by the MRN complex: break it to make it.

Authors:  Roland Kanaar; Claire Wyman
Journal:  Cell       Date:  2008-10-03       Impact factor: 41.582

Review 3.  Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.

Authors:  Tanya T Paull
Journal:  DNA Repair (Amst)       Date:  2010-11-02

Review 4.  The MRN complex in double-strand break repair and telomere maintenance.

Authors:  Brandon J Lamarche; Nicole I Orazio; Matthew D Weitzman
Journal:  FEBS Lett       Date:  2010-07-24       Impact factor: 4.124

5.  The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.

Authors:  Katja Lammens; Derk J Bemeleit; Carolin Möckel; Emanuel Clausing; Alexandra Schele; Sophia Hartung; Christian B Schiller; Maria Lucas; Christof Angermüller; Johannes Söding; Katja Strässer; Karl-Peter Hopfner
Journal:  Cell       Date:  2011-04-01       Impact factor: 41.582

Review 6.  The MRE11 complex: starting from the ends.

Authors:  Travis H Stracker; John H J Petrini
Journal:  Nat Rev Mol Cell Biol       Date:  2011-02       Impact factor: 94.444

7.  Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair.

Authors:  Debanu Das; Davide Moiani; Herbert L Axelrod; Mitchell D Miller; Daniel McMullan; Kevin K Jin; Polat Abdubek; Tamara Astakhova; Prasad Burra; Dennis Carlton; Hsiu-Ju Chiu; Thomas Clayton; Marc C Deller; Lian Duan; Dustin Ernst; Julie Feuerhelm; Joanna C Grant; Anna Grzechnik; Slawomir K Grzechnik; Gye Won Han; Lukasz Jaroszewski; Heath E Klock; Mark W Knuth; Piotr Kozbial; S Sri Krishna; Abhinav Kumar; David Marciano; Andrew T Morse; Edward Nigoghossian; Linda Okach; Jessica Paulsen; Ron Reyes; Christopher L Rife; Natasha Sefcovic; Henry J Tien; Christine B Trame; Henry van den Bedem; Dana Weekes; Qingping Xu; Keith O Hodgson; John Wooley; Marc-André Elsliger; Ashley M Deacon; Adam Godzik; Scott A Lesley; John A Tainer; Ian A Wilson
Journal:  J Mol Biol       Date:  2010-02-01       Impact factor: 5.469

8.  Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.

Authors:  R Scott Williams; Gabriel Moncalian; Jessica S Williams; Yoshiki Yamada; Oliver Limbo; David S Shin; Lynda M Groocock; Dana Cahill; Chiharu Hitomi; Grant Guenther; Davide Moiani; James P Carney; Paul Russell; John A Tainer
Journal:  Cell       Date:  2008-10-03       Impact factor: 41.582

Review 9.  DNA end resection: many nucleases make light work.

Authors:  Eleni P Mimitou; Lorraine S Symington
Journal:  DNA Repair (Amst)       Date:  2009-05-26

10.  RAD50 and NBS1 form a stable complex functional in DNA binding and tethering.

Authors:  Eddy van der Linden; Humberto Sanchez; Eri Kinoshita; Roland Kanaar; Claire Wyman
Journal:  Nucleic Acids Res       Date:  2009-01-16       Impact factor: 16.971
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  9 in total

1.  The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.

Authors:  Jun Hyun Kim; Malgorzata Grosbart; Roopesh Anand; Claire Wyman; Petr Cejka; John H J Petrini
Journal:  Cell Rep       Date:  2017-01-10       Impact factor: 9.423

2.  Disruption of the bacteriophage T4 Mre11 dimer interface reveals a two-state mechanism for exonuclease activity.

Authors:  Dustin W Albrecht; Timothy J Herdendorf; Scott W Nelson
Journal:  J Biol Chem       Date:  2012-07-13       Impact factor: 5.157

3.  Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.

Authors:  Yang Gao; Scott W Nelson
Journal:  J Biol Chem       Date:  2014-07-30       Impact factor: 5.157

4.  A network of allosterically coupled residues in the bacteriophage T4 Mre11-Rad50 complex.

Authors:  Yang Gao; Jennifer R Meyer; Scott W Nelson
Journal:  Protein Sci       Date:  2016-09-16       Impact factor: 6.725

5.  Interdependence of the rad50 hook and globular domain functions.

Authors:  Marcel Hohl; Tomasz Kochańczyk; Cristina Tous; Andrés Aguilera; Artur Krężel; John H J Petrini
Journal:  Mol Cell       Date:  2015-01-15       Impact factor: 17.970

6.  Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

Authors:  Hikmat Al-Ahmadie; Gopa Iyer; Marcel Hohl; Saurabh Asthana; Akiko Inagaki; Nikolaus Schultz; Aphrothiti J Hanrahan; Sasinya N Scott; A Rose Brannon; Gregory C McDermott; Mono Pirun; Irina Ostrovnaya; Philip Kim; Nicholas D Socci; Agnes Viale; Gary K Schwartz; Victor Reuter; Bernard H Bochner; Jonathan E Rosenberg; Dean F Bajorin; Michael F Berger; John H J Petrini; David B Solit; Barry S Taylor
Journal:  Cancer Discov       Date:  2014-06-16       Impact factor: 39.397

7.  Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins.

Authors:  Indrajeet Ghodke; K Muniyappa
Journal:  J Biol Chem       Date:  2013-02-26       Impact factor: 5.157

8.  Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.

Authors:  Tasida Barfoot; Timothy J Herdendorf; Bryanna R Behning; Bradley A Stohr; Yang Gao; Kenneth N Kreuzer; Scott W Nelson
Journal:  J Biol Chem       Date:  2015-08-04       Impact factor: 5.157

9.  Eukaryotic Rad50 functions as a rod-shaped dimer.

Authors:  Young Bong Park; Marcel Hohl; Michał Padjasek; Eunyoung Jeong; Kyeong Sik Jin; Artur Krężel; John H J Petrini; Yunje Cho
Journal:  Nat Struct Mol Biol       Date:  2017-01-30       Impact factor: 15.369
  9 in total

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