BACKGROUND: Based on promising results from laboratory studies, we hypothesized that pneumococcal vaccination would protect patients from myocardial infarction. METHODS: We conducted a hospital-based case-control study that included patients considered to be at risk of myocardial infarction. We used health databases to obtain hospital diagnoses and vaccination status. We compared patients who had been admitted for treatment of myocardial infarction with patients admitted to a surgical department in the same hospital for a reason other than myocardial infarction between 1997 and 2003. RESULTS: We found a total of 43 209 patients who were at risk; of these, we matched 999 cases and 3996 controls according to age, sex and year of hospital admission. Cases were less likely than controls to have been vaccinated (adjusted odds ratio [OR] 0.53, 95% confidence interval [CI] 0.40-0.70). This putative protective role of the vaccine was not observed for patients who had received the vaccine up to 1 year before myocardial infarction (adjusted OR 0.85, 95% CI 0.54-1.33). In contrast, if vaccination had occurred 2 years or more before the hospital admission, the association was stronger (adjusted OR 0.33, 95% CI 0.20-0.46). INTERPRETATION: Pneumococcal vaccination was associated with a decrease of more than 50% in the rate myocardial infarction 2 years after exposure. If confirmed, this association should generate interest in exploring the putative mechanisms and may offer another reason to promote pneumococcal vaccination.
BACKGROUND: Based on promising results from laboratory studies, we hypothesized that pneumococcal vaccination would protect patients from myocardial infarction. METHODS: We conducted a hospital-based case-control study that included patients considered to be at risk of myocardial infarction. We used health databases to obtain hospital diagnoses and vaccination status. We compared patients who had been admitted for treatment of myocardial infarction with patients admitted to a surgical department in the same hospital for a reason other than myocardial infarction between 1997 and 2003. RESULTS: We found a total of 43 209 patients who were at risk; of these, we matched 999 cases and 3996 controls according to age, sex and year of hospital admission. Cases were less likely than controls to have been vaccinated (adjusted odds ratio [OR] 0.53, 95% confidence interval [CI] 0.40-0.70). This putative protective role of the vaccine was not observed for patients who had received the vaccine up to 1 year before myocardial infarction (adjusted OR 0.85, 95% CI 0.54-1.33). In contrast, if vaccination had occurred 2 years or more before the hospital admission, the association was stronger (adjusted OR 0.33, 95% CI 0.20-0.46). INTERPRETATION:Pneumococcal vaccination was associated with a decrease of more than 50% in the rate myocardial infarction 2 years after exposure. If confirmed, this association should generate interest in exploring the putative mechanisms and may offer another reason to promote pneumococcal vaccination.
Authors: Christopher P Cannon; Eugene Braunwald; Carolyn H McCabe; J Thomas Grayston; Brent Muhlestein; Robert P Giugliano; Richard Cairns; Allan M Skene Journal: N Engl J Med Date: 2005-04-21 Impact factor: 91.245
Authors: Christopher M O'Connor; Michael W Dunne; Marc A Pfeffer; Joseph B Muhlestein; Louis Yao; Sandeep Gupta; Rebecca J Benner; Marian R Fisher; Thomas D Cook Journal: JAMA Date: 2003-09-17 Impact factor: 56.272
Authors: Christoph J Binder; Sohvi Hörkkö; Asheesh Dewan; Mi-Kyung Chang; Emily P Kieu; Carl S Goodyear; Peter X Shaw; Wulf Palinski; Joseph L Witztum; Gregg J Silverman Journal: Nat Med Date: 2003-05-12 Impact factor: 53.440
Authors: Angel Vila-Corcoles; Inmaculada Hospital-Guardiola; Olga Ochoa-Gondar; Cinta de Diego; Elisabet Salsench; Xavier Raga; Cruz M Fuentes-Bellido Journal: BMC Public Health Date: 2010-01-19 Impact factor: 3.295