Literature DB >> 24757525

Advances in immune-modulating therapies to treat atherosclerotic cardiovascular diseases.

Kuang-Yuh Chyu1, Prediman K Shah2.   

Abstract

In addition to hypercholesterolemia, innate and adaptive immune mechanisms play a critical role in atherogenesis, thus making immune-modulation therapy a potentially attractive way of managing atherosclerotic cardiovascular disease. These immune-modulation strategies include both active and passive immunization and confer beneficial reduction in atherosclerosis. Preclinical studies have demonstrated promising results and we review current knowledge on the complex role of the immune system and the potential for immunization as an immune-modulation therapy for atherosclerosis.

Entities:  

Keywords:  atherosclerosis; immune response; immunization

Year:  2014        PMID： 24757525      PMCID： PMC3991155          DOI： 10.1177/2051013613514327

Source DB:  PubMed          Journal:  Ther Adv Vaccines        ISSN： 2051-0136


  101 in total

1.  IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis.

Authors:  Christoph J Binder; Karsten Hartvigsen; Mi-Kyung Chang; Marina Miller; David Broide; Wulf Palinski; Linda K Curtiss; Maripat Corr; Joseph L Witztum
Journal:  J Clin Invest       Date:  2004-08       Impact factor: 14.808

Review 2.  Natural IgM antibodies against oxidation-specific epitopes.

Authors:  Christoph J Binder
Journal:  J Clin Immunol       Date:  2010-05       Impact factor: 8.317

3.  Phosphorylcholine-targeting immunization reduces atherosclerosis.

Authors:  Giuseppina Caligiuri; Jamila Khallou-Laschet; Marta Vandaele; Anh-Thu Gaston; Sandrine Delignat; Chantal Mandet; Heinz V Kohler; Srini V Kaveri; Antonino Nicoletti
Journal:  J Am Coll Cardiol       Date:  2007-07-23       Impact factor: 24.094

4.  Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis. A case-control study. The ARIC Study Investigators. Atherosclerosis Risk in Communities.

Authors:  C Iribarren; A R Folsom; D R Jacobs; M D Gross; J D Belcher; J H Eckfeldt
Journal:  Arterioscler Thromb Vasc Biol       Date:  1997-06       Impact factor: 8.311

5.  Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis.

Authors:  C W Rittershaus; D P Miller; L J Thomas; M D Picard; C M Honan; C D Emmett; C L Pettey; H Adari; R A Hammond; D T Beattie; A D Callow; H C Marsh; U S Ryan
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-09       Impact factor: 8.311

6.  Immunization with homologous oxidized low density lipoprotein reduces neointimal formation after balloon injury in hypercholesterolemic rabbits.

Authors:  J Nilsson; F Calara; J Regnstrom; A Hultgardh-Nilsson; S Ameli; B Cercek; P K Shah
Journal:  J Am Coll Cardiol       Date:  1997-12       Impact factor: 24.094

7.  Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65.

Authors:  Q Xu; H Dietrich; H J Steiner; A M Gown; B Schoel; G Mikuz; S H Kaufmann; G Wick
Journal:  Arterioscler Thromb       Date:  1992-07

8.  LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis.

Authors:  X Zhou; G Caligiuri; A Hamsten; A K Lefvert; G K Hansson
Journal:  Arterioscler Thromb Vasc Biol       Date:  2001-01       Impact factor: 8.311

9.  Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease.

Authors:  T Lehtimäki; S Lehtinen; T Solakivi; M Nikkilä; O Jaakkola; H Jokela; S Ylä-Herttuala; J S Luoma; T Koivula; T Nikkari
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-01       Impact factor: 8.311

10.  Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis.

Authors:  T van Es; G H M van Puijvelde; A C Foks; K L L Habets; I Bot; E Gilboa; T J C Van Berkel; J Kuiper
Journal:  Atherosclerosis       Date:  2009-08-31       Impact factor: 5.162
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  2 in total

1.  A potent multivalent vaccine for modulation of immune system in atherosclerosis: an in silico approach.

Authors:  Ahmad Karkhah; Jafar Amani
Journal:  Clin Exp Vaccine Res       Date:  2016-01-27

2.  Simvastatin Efficiently Lowers Small LDL-IgG Immune Complex Levels: A Therapeutic Quality beyond the Lipid-Lowering Effect.

Authors:  Gerd Hörl; Harald Froehlich; Ulrika Ferstl; Gerhard Ledinski; Josepha Binder; Gerhard Cvirn; Tatjana Stojakovic; Michael Trauner; Christoph Koidl; Erwin Tafeit; Karin Amrein; Hubert Scharnagl; Günther Jürgens; Seth Hallström
Journal:  PLoS One       Date:  2016-02-03       Impact factor: 3.240
  2 in total

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