| Literature DB >> 16759872 |
Anne Beauchard1, Yoan Ferandin, Stéphane Frère, Olivier Lozach, Mélina Blairvacq, Laurent Meijer, Valérie Thiéry, Thierry Besson.
Abstract
In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.Entities:
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Year: 2006 PMID： 16759872 DOI： 10.1016/j.bmc.2006.05.036
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641