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Literature DB >> 18805697

Synthesis and solution conformation studies of the modified nucleoside N(4),2'-O-dimethylcytidine (m(4)Cm) and its analogues.

Abstract

The dimethylated ribosomal nucleoside m(4)Cm and its monomethylated analogues Cm and m(4)C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.

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Year: 2008 PMID： 18805697 PMCID： PMC2583172 DOI： 10.1016/j.bmc.2008.09.016

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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6 in total

1. Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products.

Authors: Hari K Akula; Hariprasad Kokatla; Graciela Andrei; Robert Snoeck; Dominique Schols; Jan Balzarini; Lijia Yang; Mahesh K Lakshman
Journal: Org Biomol Chem Date: 2017-02-01 Impact factor: 3.876

2. Facile Modifications at the C4 Position of Pyrimidine Nucleosides via In Situ Amide Activation with 1H-Benzotriazol-1-yloxy-tris(dimethyl-amino)phosphonium Hexafluorophosphate.

Authors: Hari K Akula; Mahesh K Lakshman
Journal: Curr Protoc Nucleic Acid Chem Date: 2019-01-28