Literature DB >> 1879941

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.

K A Rockett1, M M Awburn, W B Cowden, I A Clark.   

Abstract

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.

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Year:  1991        PMID： 1879941      PMCID： PMC258164          DOI： 10.1128/iai.59.9.3280-3283.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  47 in total

1.  Inhibitor of Clostridium perfringens formed by heating sodium nitrite in a chemically defined medium.

Authors:  D M Moran; S R Tannenbaum; M C Archer
Journal:  Appl Microbiol       Date:  1975-11

2.  Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor.

Authors:  R J Gryglewski; R M Palmer; S Moncada
Journal:  Nature       Date:  1986 Apr 3-9       Impact factor: 49.962

3.  Serum tumor necrosis factor associated with malaria in patients in the Solomon Islands.

Authors:  G A Butcher; T Garland; A B Ajdukiewicz; I A Clark
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Sep-Oct       Impact factor: 2.184

4.  Cellular mechanisms of nonspecific immunity to intracellular infection: cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes.

Authors:  S J Green; S Mellouk; S L Hoffman; M S Meltzer; C A Nacy
Journal:  Immunol Lett       Date:  1990-08       Impact factor: 3.685

5.  Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

Authors:  S L James; J Glaven
Journal:  J Immunol       Date:  1989-12-15       Impact factor: 5.422

6.  Localization of nitric oxide synthase indicating a neural role for nitric oxide.

Authors:  D S Bredt; P M Hwang; S H Snyder
Journal:  Nature       Date:  1990-10-25       Impact factor: 49.962

7.  The effect of nitric oxide on bacteria.

Authors:  J L SHANK; J H SILLIKER; R H HARPER
Journal:  Appl Microbiol       Date:  1962-05

8.  TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.

Authors:  D Kwiatkowski; A V Hill; I Sambou; P Twumasi; J Castracane; K R Manogue; A Cerami; D R Brewster; B M Greenwood
Journal:  Lancet       Date:  1990-11-17       Impact factor: 79.321

9.  Formation of free radicals and nitric oxide derivative of hemoglobin in rats during shock syndrome.

Authors:  U Westenberger; S Thanner; H H Ruf; K Gersonde; G Sutter; O Trentz
Journal:  Free Radic Res Commun       Date:  1990

10.  L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation.

Authors:  A Nüssler; J C Drapier; L Rénia; S Pied; F Miltgen; M Gentilini; D Mazier
Journal:  Eur J Immunol       Date:  1991-01       Impact factor: 5.532
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  75 in total

1.  Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria.

Authors:  D J Perkins; P G Kremsner; D Schmid; M A Misukonis; M A Kelly; J B Weinberg
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

2.  The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria.

Authors:  Morris O Makobongo; George Riding; Huji Xu; Chakrit Hirunpetcharat; Dianne Keough; John de Jersey; Peter Willadsen; Michael F Good
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-19       Impact factor: 11.205

3.  Nitric oxide inhibits irreversibly P815 cell proliferation: involvement of potassium channels.

Authors:  R S A Costa; J Assreuy
Journal:  Cell Prolif       Date:  2002-12       Impact factor: 6.831

4.  Gamma interferon production is critical for protective immunity to infection with blood-stage Plasmodium berghei XAT but neither NO production nor NK cell activation is critical.

Authors:  T Yoneto; T Yoshimoto; C R Wang; Y Takahama; M Tsuji; S Waki; H Nariuchi
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

5.  Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria.

Authors:  David Burgner; Stanley Usen; Kirk Rockett; Muminatou Jallow; Hans Ackerman; Alessandra Cervino; Margaret Pinder; Dominic P Kwiatkowski
Journal:  Hum Genet       Date:  2003-01-28       Impact factor: 4.132

6.  S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.

Authors:  Alex Schudel; Timothy Kassis; J Brandon Dixon; Susan N Thomas
Journal:  Adv Healthc Mater       Date:  2015-05-04       Impact factor: 9.933

7.  Stimulation of nitric oxide production in macrophages by Babesia bovis.

Authors:  R W Stich; L K Shoda; M Dreewes; B Adler; T W Jungi; W C Brown
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

8.  The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

Authors:  I Vouldoukis; V Riveros-Moreno; B Dugas; F Ouaaz; P Bécherel; P Debré; S Moncada; M D Mossalayi
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei.

Authors:  Dietmar Steverding; Xia Wang; Darren W Sexton
Journal:  Parasitol Res       Date:  2009-07-16       Impact factor: 2.289

10.  Levels of circulating nitrate/nitrite and gamma interferon not increased in uncomplicated malaria.

Authors:  D Torre; G Ferrario; A Matteelli; F Speranza; M Giola; A Pugliese; C Cantamessa; G Carosi; G P Fiori
Journal:  Infection       Date:  1998 Sep-Oct       Impact factor: 3.553
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