| Literature DB >> 9795789 |
D Torre1, G Ferrario, A Matteelli, F Speranza, M Giola, A Pugliese, C Cantamessa, G Carosi, G P Fiori.
Abstract
The purpose of this study was to evaluate nitric oxide (NO) activity in patients with uncomplicated malaria. Lipopolysaccharide and gamma interferon (IFN-gamma) are potent inducers of NO by inducing production of NO synthase. NO activity was determined by measuring serum levels of nitrite/nitrate (metabolic end products of NO), and IFN-gamma in patients with uncomplicated malaria, mostly caused by Plasmodium falciparum. Neither serum levels of nitrite/nitrate nor of IFN-gamma were significantly increased in patients with uncomplicated malaria, especially in patients with P. falciparum infection, and in those with high parasitaemia. These results show that NO cannot play a role in uncomplicated malaria, and it is still debatable if NO production in this infection has beneficial or detrimental effects.Entities:
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Year: 1998 PMID： 9795789 DOI： 10.1007/bf02962252
Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553